Lepage P, Van de Perre P, Nsengumuremyi F, Van Goethem C, Bogaerts J, Hitimana D G
Department of Paediatrics, and Center Hospitalier de Kigali, Rwanda.
Acta Paediatr Scand. 1989 Sep;78(5):763-6. doi: 10.1111/j.1651-2227.1989.tb11140.x.
In Rwanda, both HIV infection and bacteraemia represent major health problems among paediatric populations. We carried out of prospective study of determine if bacteraemia is a marker of HIV infection among ambulatory and hospitalized Rwandese children. All children presenting at the Department of Paediatrics of the Center Hospitalier de Kigali who had their blood cultured during a two-month period were eligible for the study. One hundred and thirty-five children were included in the study. A pathogen was isolated from 36 children (26.7%): S. typhimurium (10 cases), S. enteritidis (6), S. typhi (4), Str. pneumoniae (9). H. influenzae (6) and S. aureus (1). No association was found between bacteraemia and HIV seropositivity when all the children were considered. However, among patients less than 2 years old, bacteraemic subjects were more frequently (p less than 0.05) HIV seropositive (44%) than those with negative blood cultures (19%). Our study shows that in young children in Central Africa, the presence of bacteraemia may be an important marker of HIV seropositivity.
在卢旺达，艾滋病毒感染和菌血症都是儿童群体中的主要健康问题。我们进行了一项前瞻性研究，以确定菌血症是否为卢旺达门诊及住院儿童艾滋病毒感染的一个指标。在基加利中心医院儿科就诊且在两个月期间进行了血培养的所有儿童均符合该研究的条件。135名儿童被纳入研究。从36名儿童（26.7%）中分离出病原体：鼠伤寒沙门氏菌（10例）、肠炎沙门氏菌（6例）、伤寒沙门氏菌（4例）、肺炎链球菌（9例）、流感嗜血杆菌（6例）和金黄色葡萄球菌（1例）。当把所有儿童都纳入考虑时，未发现菌血症与艾滋病毒血清阳性之间存在关联。然而，在2岁以下的患者中，有菌血症的受试者艾滋病毒血清阳性的比例（44%）高于血培养阴性的受试者（19%），差异有统计学意义（p小于0.05）。我们的研究表明，在中非的幼儿中，菌血症的存在可能是艾滋病毒血清阳性的一个重要指标。
