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SIV encephalitis lesions are composed of CD163(+) macrophages present in the central nervous system during early SIV infection and SIV-positive macrophages recruited terminally with AIDS.猴免疫缺陷病毒（SIV）脑炎病变由早期SIV感染期间存在于中枢神经系统中的CD163（+）巨噬细胞以及在艾滋病末期终末募集的SIV阳性巨噬细胞组成。
Am J Pathol. 2015 Jun;185(6):1649-65. doi: 10.1016/j.ajpath.2015.01.033. Epub 2015 May 8.
2
Multivariate normative comparison, a novel method for more reliably detecting cognitive impairment in HIV infection.多变量规范比较，一种更可靠地检测HIV感染中认知障碍的新方法。
AIDS. 2015 Mar 13;29(5):547-57. doi: 10.1097/QAD.0000000000000573.
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Imaging atherosclerotic burden and inflammation: insights into the spectrum of atherosclerotic disease in HIV.成像动脉粥样硬化负担与炎症：深入了解HIV相关动脉粥样硬化疾病谱
J Nucl Cardiol. 2015 Apr;22(2):381-4. doi: 10.1007/s12350-014-0044-9. Epub 2014 Dec 24.
4
Anti-α4 antibody treatment blocks virus traffic to the brain and gut early, and stabilizes CNS injury late in infection.抗α4抗体治疗可早期阻断病毒向脑和肠道的传播，并在感染后期稳定中枢神经系统损伤。
PLoS Pathog. 2014 Dec 11;10(12):e1004533. doi: 10.1371/journal.ppat.1004533. eCollection 2014 Dec.
5
Progressive increase in central nervous system immune activation in untreated primary HIV-1 infection.未经治疗的原发性HIV-1感染中中枢神经系统免疫激活的渐进性增加。
J Neuroinflammation. 2014 Dec 3;11:199. doi: 10.1186/s12974-014-0199-y.
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Emerging roles of pericytes in the regulation of the neurovascular unit in health and disease.周细胞在健康和疾病状态下对神经血管单元调节中的新作用。
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Serious Non-AIDS events: Immunopathogenesis and interventional strategies.严重非艾滋病事件：免疫发病机制和干预策略。
AIDS Res Ther. 2013 Dec 13;10(1):29. doi: 10.1186/1742-6405-10-29.
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9
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Monocyte activation markers in cerebrospinal fluid associated with impaired neurocognitive testing in advanced HIV infection.晚期 HIV 感染患者脑脊液中单核细胞激活标志物与神经认知测试受损相关。
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对HIV感染中终末器官损伤的见解：SIV脑炎中单核细胞向脑内迁移的动态变化

Insights into end-organ injury in HIV infection: dynamics of monocyte trafficking to the brain in SIV encephalitis.

作者信息

Persidsky Yuri

机构信息

Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania.

出版信息

Am J Pathol. 2015 Jun;185(6):1548-51. doi: 10.1016/j.ajpath.2015.03.001. Epub 2015 May 8.

DOI:10.1016/j.ajpath.2015.03.001
PMID:25963553
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4450311/
Abstract

This commentary highlights the article by Nowlin et al, which explores the dynamic roles of macrophages in early and late central nervous system lentiviral disease.

摘要

本述评重点介绍了Nowlin等人的文章，该文章探讨了巨噬细胞在中枢神经系统慢病毒疾病早期和晚期的动态作用。