McDonald B E, Gerrard J M, Bruce V M, Corner E J
Department of Foods and Nutrition, University of Manitoba, Winnipeg, Canada.
Am J Clin Nutr. 1989 Dec;50(6):1382-8. doi: 10.1093/ajcn/50.6.1382.
The effect of dietary fatty acid composition on plasma lipids and eicosanoid production was studied in normolipidemic men. Approximately 75% of the fat in the diet was provided by a mixture of fats (MF) during the 6-d pre and postperiods and either canola oil (CO) or sunflower oil (SO) during the two 18-d experimental periods. Saturated, monounsaturated, and polyunsaturated fatty acids provided 14%, 15%, and 7%; 5%, 20%, and 10%; and 7%, 7%, and 22%, respectively, of total dietary energy in the MF, CO, and SO diets, respectively. The CO and SO diets produced similar decreases in plasma total (20% and 15%, respectively) and low-density lipoprotein (25% and 21%, respectively) cholesterol. Plasma high-density lipoprotein cholesterol and triglyceride concentrations were not altered by either fat source. Bleeding time was longer and in vivo 1-keto-PGF1 alpha production was greater (p less than 0.05) when on the CO diet than when on the MF diet. The hypocholesterolemic and antithrombotic effects of the CO diet were equivalent to those of the SO diet.
在血脂正常的男性中研究了膳食脂肪酸组成对血浆脂质和类二十烷酸生成的影响。在6天的前后阶段，饮食中约75%的脂肪由混合脂肪（MF）提供，在两个18天的实验阶段，分别由菜籽油（CO）或向日葵油（SO）提供。饱和脂肪酸、单不饱和脂肪酸和多不饱和脂肪酸分别提供了MF、CO和SO饮食中总膳食能量的14%、15%和7%；5%、20%和10%；以及7%、7%和22%。CO和SO饮食使血浆总胆固醇（分别降低20%和15%）和低密度脂蛋白胆固醇（分别降低25%和21%）产生了相似程度的下降。血浆高密度脂蛋白胆固醇和甘油三酯浓度未因任何一种脂肪来源而改变。与MF饮食相比，食用CO饮食时出血时间更长，体内1-酮基-PGF1α生成量更大（p<0.05）。CO饮食的降胆固醇和抗血栓形成作用与SO饮食相当。
