系统疫苗学。
Systems vaccinology.
机构信息
Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA.
出版信息
Immunity. 2010 Oct 29;33(4):516-29. doi: 10.1016/j.immuni.2010.10.006.
Abstract
Vaccination is one of the greatest triumphs of modern medicine, yet we remain largely ignorant of the mechanisms by which successful vaccines stimulate protective immunity. Two recent advances are beginning to illuminate such mechanisms: realization of the pivotal role of the innate immune system in sensing microbes and stimulating adaptive immunity, and advances in systems biology. Recent studies have used systems biology approaches to obtain a global picture of the immune responses to vaccination in humans. This has enabled the identification of early innate signatures that predict the immunogenicity of vaccines, and identification of potentially novel mechanisms of immune regulation. Here, we review these advances and critically examine the potential opportunities and challenges posed by systems biology in vaccine development.
摘要
疫苗接种是现代医学的最大成就之一，但我们对成功的疫苗如何刺激保护性免疫的机制仍知之甚少。最近的两项进展开始揭示这些机制：认识到先天免疫系统在感知微生物和刺激适应性免疫方面的关键作用，以及系统生物学的进展。最近的研究使用系统生物学方法来获得人类对疫苗接种的免疫反应的全貌。这使得能够识别预测疫苗免疫原性的早期先天特征，并确定潜在的新型免疫调节机制。在这里，我们回顾这些进展，并批判性地检查系统生物学在疫苗开发中带来的潜在机遇和挑战。
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本文引用的文献
1
Programming dendritic cells to induce T(H)2 and tolerogenic responses.编程树突状细胞诱导 T(H)2 和耐受反应。
Nat Immunol. 2010 Aug;11(8):647-55. doi: 10.1038/ni.1894. Epub 2010 Jul 20.
2
The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.辅助性 T 细胞 2 型应答半胱氨酸蛋白酶需要树突状细胞-嗜碱性粒细胞通过 ROS 介导的信号转导进行合作。
Nat Immunol. 2010 Jul;11(7):608-17. doi: 10.1038/ni.1883. Epub 2010 May 23.
3
New adjuvants for human vaccines.新型人用疫苗佐剂。
Curr Opin Immunol. 2010 Jun;22(3):411-6. doi: 10.1016/j.coi.2010.04.004. Epub 2010 May 11.
4
Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques.猕猴中疫苗和佐剂诱导的对猴免疫缺陷病毒黏膜传播控制的先天免疫和适应性免疫相关因素。
Proc Natl Acad Sci U S A. 2010 May 25;107(21):9843-8. doi: 10.1073/pnas.0911932107. Epub 2010 May 10.
5
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.模式识别受体在天然免疫中的作用：Toll 样受体更新。
Nat Immunol. 2010 May;11(5):373-84. doi: 10.1038/ni.1863. Epub 2010 Apr 20.
6
Targeting Toll-like receptors: emerging therapeutics?靶向 Toll 样受体：新兴治疗方法？
Nat Rev Drug Discov. 2010 Apr;9(4):293-307. doi: 10.1038/nrd3203.
7
Circulating antitoxin at the onset of diphtheria in 425 patients.425例白喉患者发病时的循环抗毒素情况。
J Immunol. 1946 Dec;54(4):325-47.
8
Cell type-specific gene expression differences in complex tissues.复杂组织中的细胞类型特异性基因表达差异。
Nat Methods. 2010 Apr;7(4):287-9. doi: 10.1038/nmeth.1439. Epub 2010 Mar 7.
9
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Annu Rev Immunol. 2010;28:535-71. doi: 10.1146/annurev-immunol-030409-101221.
10
Integrating genomic signatures for immunologic discovery.整合基因组特征以进行免疫发现。
Immunity. 2010 Feb 26;32(2):152-61. doi: 10.1016/j.immuni.2010.02.001.
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