Shin Yu Seob, On Ji Won, Kim Myung Ki
Department of Urology, Chonbuk National University Medical School, Institute for Medical Sciences, Chonbuk National University and Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.
Korean J Urol. 2015 May;56(5):393-7. doi: 10.4111/kju.2015.56.5.393. Epub 2015 Apr 21.
Stress urinary incontinence (SUI) is one of the most common lower urinary tract symptoms in women. We analyzed age-associated changes in urodynamic parameters in women with SUI.
We analyzed the urodynamic study (UDS) results of patients with urodynamically proven SUI between March 2008 and July 2014. In uroflowmetry, maximal flow rate (Qmax), time to Qmax, voided volume, and postvoid residual urine volume (PVR) and filling cystometry data including first, strong desire to void and Valsalva leak point pressure (VLPP) were measured. Also, Qmax and detrusor pressure at Qmax (Pdet@Qmax) of voiding cystometry data were analyzed.
The subjects included 776 patients. Among the patients, 151 were withdrawn because of incomplete UDS data or because they met the exclusion criteria. A total of 625 patients enrolled in our study. The mean age of the population was 57.3 years. The mean Qmax, voided volume, voiding time, and PVR were 26.2 mL/s, 292.1 mL, 25.7 s, and 31.7 mL, respectively. Qmax (p=0.001) in uroflowmetry, PVR (p=0.042), first desire to void (p=0.042), Pdet@Qmax (p=0.016), and the bladder contractility index (p=0.046) were significantly different between the age groups. Qmax and Pdet@Qmax were decreased and PVR was increased significantly with age after 60 years.
Older women with SUI also have worsened voiding function with age as the results of urodynamic parameters. Specifically, detrusor contractility decreased with age after 60 years.
压力性尿失禁（SUI）是女性最常见的下尿路症状之一。我们分析了压力性尿失禁女性患者尿动力学参数的年龄相关变化。
我们分析了 2008 年 3 月至 2014 年 7 月间尿动力学确诊为压力性尿失禁患者的尿动力学研究（UDS）结果。在尿流率测定中，测量最大尿流率（Qmax）、达到 Qmax 的时间、排尿量、排尿后残余尿量（PVR）以及充盈性膀胱测压数据，包括首次强烈排尿欲望和瓦尔萨尔瓦漏尿点压力（VLPP）。此外，还分析了排尿性膀胱测压数据中的 Qmax 和 Qmax 时的逼尿肌压力（Pdet@Qmax）。
研究对象包括 776 名患者。其中，151 名因 UDS 数据不完整或符合排除标准而退出。共有 625 名患者纳入我们的研究。总体平均年龄为 57.3 岁。平均 Qmax、排尿量、排尿时间和 PVR 分别为 26.2 mL/s、292.1 mL、25.7 s 和 31.7 mL。尿流率测定中的 Qmax（p = 0.001）、PVR（p = 0.042）、首次排尿欲望（p = 0.042）、Pdet@Qmax（p = 0.016）以及膀胱收缩力指数（p = 0.046）在各年龄组之间存在显著差异。60 岁以后，Qmax 和 Pdet@Qmax 随年龄增长显著降低，PVR 显著增加。
压力性尿失禁的老年女性随着年龄增长，尿动力学参数显示排尿功能也会恶化。具体而言，60 岁以后逼尿肌收缩力随年龄下降。
