Kakizaki Hidehiro, Matsuura Shinobu, Mitsui Takahiko, Ameda Kaname, Tanaka Hiroshi, Koyanagi Tomohiko
Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Urology. 2002 Jan;59(1):58-62. doi: 10.1016/s0090-4295(01)01487-x.
To examine the sex difference in the prevalence and severity of lower urinary tract symptoms in Japanese men and women.
Of 970 individuals who attended the public lectures by urologists and a famous veterinarian that were organized as a public service of the 88th Annual Meeting of the Japanese Urological Association (June 2000, Sapporo, Japan), 677 (70%) completed the self-administered International Prostate Symptom Score (IPSS) questionnaire. The scores of 653 attendees aged 30 to 79 years (446 men, mean age 67.5 and 207 women, mean age 60.7) were the basis of this study.
A significant age-related increase in IPSS and quality-of-life score was observed in both men and women. The ratio of moderate (IPSS 8 to 19) to severe (IPSS 20 or greater) symptoms in the 50s, 60s, and 70s was 52%, 72%, and 80% in men and 27%, 36%, and 55% in women, respectively. Additional analysis in each decade showed that at age 50 years and older the total score and voiding symptom score of IPSS, as well as the quality-of-life score, were significantly greater in men than in women.
The total IPSS and quality-of-life score correlated highly with age in both sexes. At the age of 50 years and older, men had severer voiding symptoms than did women. Although the age-related changes in bladder function predispose both men and women equally to lower urinary tract symptoms, the higher incidence of bladder outlet obstruction in men having a prostate may have a significant influence on the higher voiding symptom score in men.
研究日本男性和女性下尿路症状的患病率及严重程度的性别差异。
在参加日本泌尿外科学会第88届年会（2000年6月，日本札幌）举办的由泌尿科医师和一位著名兽医主讲的公益讲座的970人中，677人（70%）完成了自行填写的国际前列腺症状评分（IPSS）问卷。本研究以653名年龄在30至79岁的参与者（446名男性，平均年龄67.5岁；207名女性，平均年龄60.7岁）的评分作为基础。
男性和女性的IPSS及生活质量评分均随年龄显著增加。在50多岁、60多岁和70多岁人群中，男性中度（IPSS 8至19）与重度（IPSS 20及以上）症状的比例分别为52%、72%和80%，女性分别为27%、36%和55%。对每个十年的进一步分析显示，50岁及以上男性的IPSS总分、排尿症状评分以及生活质量评分均显著高于女性。
IPSS总分及生活质量评分在两性中均与年龄高度相关。50岁及以上男性的排尿症状比女性更严重。尽管膀胱功能随年龄的变化使男性和女性患下尿路症状的几率相同，但男性前列腺导致的膀胱出口梗阻发生率较高，可能对男性较高的排尿症状评分有重大影响。
