Department of Dermatology, Hospital San Pedro, Logroño, Spain.
Department of Pathology, Salamanca University Hospital, Paseo San Vicente, 88-182, 37007, Salamanca, Spain.
Br J Dermatol. 2015 Oct;173(4):1050-3. doi: 10.1111/bjd.13894. Epub 2015 Aug 19.
Cutaneous graft-versus-host disease (GVHD) is a frequent complication of allogeneic bone marrow transplant and haematopoietic cell transplantation, but it is rarely presented as a Wolf's isotopic response. We report a patient who developed chronic lichenoid GVHD following the dermatomes previously affected by varicella zoster virus (VZV) infection. Nineteen months later, the same patient suffered from reactivation of GVHD at the injection site of an influenza vaccination. We review the literature concerning GVHD appearing after VZV infection and discuss the possible implications of this case and the pathogenic hypotheses.
皮肤移植物抗宿主病（GVHD）是异基因骨髓移植和造血细胞移植的常见并发症，但它很少表现为沃尔夫氏同种反应。我们报告了一例患者，在先前受水痘带状疱疹病毒（VZV）感染影响的皮区发生慢性苔藓样 GVHD。19 个月后，同一位患者在流感疫苗接种部位出现 GVHD 再激活。我们回顾了有关 VZV 感染后出现 GVHD 的文献，并讨论了该病例的可能意义和发病假说。
