广泛的季节性基因表达揭示了人类免疫力和生理机能的年度差异。
Widespread seasonal gene expression reveals annual differences in human immunity and physiology.
作者信息
Dopico Xaquin Castro, Evangelou Marina, Ferreira Ricardo C, Guo Hui, Pekalski Marcin L, Smyth Deborah J, Cooper Nicholas, Burren Oliver S, Fulford Anthony J, Hennig Branwen J, Prentice Andrew M, Ziegler Anette-G, Bonifacio Ezio, Wallace Chris, Todd John A
机构信息
JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
MRC International Nutrition Group at MRC Unit The Gambia &London School of Hygiene &Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
出版信息
Nat Commun. 2015 May 12;6:7000. doi: 10.1038/ncomms8000.
Seasonal variations are rarely considered a contributing component to human tissue function or health, although many diseases and physiological process display annual periodicities. Here we find more than 4,000 protein-coding mRNAs in white blood cells and adipose tissue to have seasonal expression profiles, with inverted patterns observed between Europe and Oceania. We also find the cellular composition of blood to vary by season, and these changes, which differ between the United Kingdom and The Gambia, could explain the gene expression periodicity. With regards to tissue function, the immune system has a profound pro-inflammatory transcriptomic profile during European winter, with increased levels of soluble IL-6 receptor and C-reactive protein, risk biomarkers for cardiovascular, psychiatric and autoimmune diseases that have peak incidences in winter. Circannual rhythms thus require further exploration as contributors to various aspects of human physiology and disease.
季节性变化很少被视为影响人体组织功能或健康的一个因素，尽管许多疾病和生理过程呈现出年度周期性。在这里，我们发现白细胞和脂肪组织中有4000多种蛋白质编码mRNA具有季节性表达谱，在欧洲和大洋洲之间观察到相反的模式。我们还发现血液的细胞组成随季节变化，英国和冈比亚之间的这些差异变化可以解释基因表达的周期性。关于组织功能，在欧洲冬季，免疫系统具有深刻的促炎转录组特征，可溶性白细胞介素-6受体和C反应蛋白水平升高，这两种物质是心血管、精神和自身免疫性疾病的风险生物标志物，在冬季发病率达到峰值。因此，作为人类生理学和疾病各个方面的一个因素，年节律需要进一步探索。
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