Potelle Sven, Klein André, Foulquier François
CNRS-UMR 8576, Structural and Functional Glycobiology unit, FRABIO, University of Lille, 59655, Villeneuve d'Ascq, France.
J Inherit Metab Dis. 2015 Jul;38(4):741-51. doi: 10.1007/s10545-015-9851-7. Epub 2015 May 13.
For non specialists, Golgi is a very well known subcellular compartment involved in secretion and correct targeting of soluble and transmembrane proteins. Nevertheless, Golgi is also specifically involved in many different and diverse post-translational modifications. Through its diverse functions, Golgi is not only able to modify secreted and transmembrane proteins but also cytoplasmic proteins. The Golgi apparatus research field is so broad that an exhaustive review of this organelle is not doable here. The goal of this review is to cover the main post-translational modifications occurring at the Golgi level and present the identified associated diseases.
对于非专业人士来说，高尔基体是一个广为人知的亚细胞区室，参与可溶性和跨膜蛋白的分泌及正确靶向定位。然而，高尔基体还特别参与许多不同类型的翻译后修饰。通过其多样的功能，高尔基体不仅能够修饰分泌蛋白和跨膜蛋白，还能修饰细胞质蛋白。高尔基体研究领域非常广泛，在此无法对这个细胞器进行详尽综述。本综述的目的是涵盖在高尔基体水平发生的主要翻译后修饰，并介绍已确定的相关疾病。
