二体基因座内容图谱分析

Disomic locus content mapping.

作者信息

Morton N E

机构信息

Department of Child Health, University of Southampton, Princess Anne Hospital, United Kingdom.

出版信息

Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1421-2. doi: 10.1073/pnas.91.4.1421.

DOI:10.1073/pnas.91.4.1421

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC43170/

Abstract

A linear genetic map may be constructed from segregation of markers in DNA fragments broken by radiation or shearing and/or incorporated into a vector: this is locus content mapping. Theory for monosomic locus content mapping is extended to disomy, making the phase of heterozygous markers informative for linkage and each clone potentially informative for every chromosome. Because there is no interference among breaks and phase may be reliable inferred for all heterozygous loci, multiple pairwise mapping is especially appropriate.

摘要

线性遗传图谱可通过对经辐射或剪切而断裂的DNA片段中的标记进行分离构建，和/或将其整合到载体中构建：这就是基因座含量作图。单体型基因座含量作图理论扩展到了二体，使得杂合标记的相位对于连锁分析具有信息性，并且每个克隆对于每一条染色体都可能具有信息性。由于断裂之间不存在干扰，并且对于所有杂合基因座的相位可以可靠推断，多重成对作图尤为合适。

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