Eijzenga W, Bleiker E M A, Hahn D E E, Van der Kolk L E, Sidharta G N, Aaronson N K
Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Family Cancer Clinic, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Fam Cancer. 2015 Dec;14(4):629-36. doi: 10.1007/s10689-015-9809-9.
Only a minority of individuals who undergo cancer genetic counseling experience heightened levels of psychological distress, but many more experience a range of cancer genetic-specific psychosocial problems. The aim of this study was to estimate the prevalence of such psychosocial problems, and to identify possible demographic and clinical variables associated significantly with them. Consenting individuals scheduled to undergo cancer genetic counseling completed the Psychosocial Aspects of Hereditary Cancer (PAHC) questionnaire, the Hospital Anxiety and Depression Scale (HADS) and the Distress Thermometer (DT) prior to or immediately following their counseling session. More than half of the 137 participants reported problems on three or more domains of the PAHC, most often in the domains 'living with cancer' (84%), 'family issues' (46%), 'hereditary predisposition' (45%), and 'child-related issues' (42%). Correlations between the PAHC, the HADS and the DT were low. Previous contact with a psychosocial worker, and having a personal history of cancer were associated significantly with HADS scores, but explained little variance (9%). No background variables were associated significantly with the DT. Previous contact with a psychosocial worker, and having children were significantly associated with several PAHC domains, again explaining only a small percentage of the variance (2-14%). The majority of counselees experience specific cancer genetic counseling-related psychosocial problems. Only a few background variables are associated significantly with distress or psychosocial problems. Thus we recommend using the PAHC or a similar problem-oriented questionnaire routinely in cancer genetic counseling to identify individuals with such problems.
只有少数接受癌症遗传咨询的个体经历了心理困扰水平的提高，但更多的个体经历了一系列特定于癌症遗传的心理社会问题。本研究的目的是估计此类心理社会问题的患病率，并确定与之显著相关的可能的人口统计学和临床变量。计划接受癌症遗传咨询的同意参与的个体在咨询前或咨询后立即完成了遗传性癌症心理社会方面（PAHC）问卷、医院焦虑抑郁量表（HADS）和痛苦温度计（DT）。137名参与者中超过一半报告在PAHC的三个或更多领域存在问题，最常见的领域是“与癌症共存”（84%）、“家庭问题”（46%）、“遗传易感性”（45%）和“与孩子相关的问题”（42%）。PAHC、HADS和DT之间的相关性较低。以前与心理社会工作者接触过以及有个人癌症病史与HADS评分显著相关，但解释的方差很小（9%）。没有背景变量与DT显著相关。以前与心理社会工作者接触过以及有孩子与几个PAHC领域显著相关，同样只解释了很小比例的方差（2 - 14%）。大多数接受咨询者经历了与癌症遗传咨询相关的特定心理社会问题。只有少数背景变量与痛苦或心理社会问题显著相关。因此，我们建议在癌症遗传咨询中常规使用PAHC或类似的以问题为导向的问卷来识别有此类问题的个体。
