Huang Jian, Zheng Yaxin, Wu Wenxi, Xie Tao, Yao Hong, Pang Xiaobo, Sun Fuzhou, Ouyang Liang, Wang Jinhui
Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Oncotarget. 2015 Jul 10;6(19):17675-84. doi: 10.18632/oncotarget.3789.
China has different ethnic minorities that establish their own medical systems and practice experience for thousand years, thereafter named Chinese Ethnic Minority Traditional Drugs (CEMTDs) (http://www.cemtdd.com/index.html). Since many compounds from CEMTDs have been reported to perturb human's dysfunction network and restore human normal physiological conditions, the relationships amongst a series of compounds from specific herbs, their targets and relevant diseases have become our main focus in CEMTD modernization. Herein, we have constructed the first Chinese Ethnic Minority Traditional Drug Database (CEMTDD) mainly from Xinjiang Uygur Autonomous Region (XUAR), retrieving CEMTD-related information from different resources. CEMTDD contains about 621 herbs, 4, 060 compounds, 2, 163 targets and 210 diseases, among which most of herbs can be applied into gerontology therapy including inflammation, cardiovascular disease and neurodegenerative disease. Gerontology is highly occurred in XUAR, and has abundant experience in treating such diseases, which may benefit for developing a new gerontology therapeutic strategy. CEMTDD displays networks for intricate relationships between CEMTDs and treated diseases, as well as the interrelations between active compounds and action targets, which may shed new light on the combination therapy of CEMTDs and further understanding of their herb molecular mechanisms for better modernized utilizations of CEMTDs, especially in gerontology.
中国有不同的少数民族，他们建立了自己的医疗体系并拥有数千年的实践经验，这些药物后来被称为中国少数民族传统药物（CEMTDs）（http://www.cemtdd.com/index.html）。由于许多来自CEMTDs的化合物已被报道可扰乱人类的功能失调网络并恢复人类正常生理状态，特定草药中的一系列化合物、它们的靶点以及相关疾病之间的关系已成为我们在CEMTD现代化方面的主要关注点。在此，我们构建了首个主要来自新疆维吾尔自治区（XUAR）的中国少数民族传统药物数据库（CEMTDD），从不同资源中检索与CEMTD相关的信息。CEMTDD包含约621种草药、4060种化合物、2163个靶点和210种疾病，其中大多数草药可应用于老年病治疗，包括炎症、心血管疾病和神经退行性疾病。老年病在XUAR高发，且在治疗此类疾病方面有丰富经验，这可能有助于制定新的老年病治疗策略。CEMTDD展示了CEMTDs与所治疗疾病之间复杂关系的网络，以及活性化合物与作用靶点之间的相互关系，这可能为CEMTDs的联合治疗以及进一步理解其草药分子机制以更好地实现CEMTDs的现代化利用，尤其是在老年病学方面，提供新的思路。
