McInerney Jennie, Papasouliotis Kostas, Simpson Kerry, English Kate, Cook Simon, Milne Elspeth, Gunn-Moore Danièlle A
Small Animal Hospital, University of Glasgow, Glasgow, UK
University of Bristol, School of Veterinary Sciences, Langford Veterinary Services Diagnostic Laboratories, Bristol, UK.
J Feline Med Surg. 2016 Jun;18(6):518-25. doi: 10.1177/1098612X15583344. Epub 2015 May 13.
This case series documents five cases of pneumonia (with pleural effusion in three cases) caused by cowpox virus (CPxV) in domestic cats. Predisposition to pneumonia may have resulted from mixed infections in two cases (feline herpesvirus and Bordetella bronchiseptica in one cat, and Mycoplasma species in the other).
As well as diagnostic confirmation by previously described methods of virus isolation from skin lesions, and demonstration of pox virions in skin samples using electron microscopy and inclusion bodies in histological preparations, this is the first report of diagnosis by virus isolation from bronchoalveolar lavage fluid or pleural fluid, and demonstration of inclusion bodies in cytological preparations. This is also the first series to report treatment with interferon omega (IFN-ω). Two cats survived, both of which had been treated with IFN-ω. As CPxV represents a serious zoonotic risk it is an important differential diagnosis of pneumonia in cats.
本病例系列记录了5例家猫感染牛痘病毒（CPxV）引起的肺炎病例（其中3例伴有胸腔积液）。两例肺炎的易感性可能源于混合感染（一例猫感染猫疱疹病毒和支气管败血博德特氏菌，另一例感染支原体）。
除了通过先前描述的从皮肤损伤处分离病毒的方法进行诊断确认，以及使用电子显微镜在皮肤样本中显示痘病毒颗粒和在组织学制剂中显示包涵体之外，这是首次报告通过从支气管肺泡灌洗液或胸腔积液中分离病毒进行诊断，以及在细胞学制剂中显示包涵体。这也是首个报告使用ω干扰素（IFN-ω）进行治疗的病例系列。两只接受IFN-ω治疗的猫存活下来。由于CPxV具有严重的人畜共患病风险，它是猫肺炎的重要鉴别诊断疾病。
