MacNeill Amy L
Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Pathogens. 2022 Aug 9;11(8):892. doi: 10.3390/pathogens11080892.
This review provides a brief history of the impacts that a human-specific Orthopoxvirus (OPXV), , had on mankind, recalls how critical vaccination was for the eradication of this disease, and discusses the consequences of discontinuing vaccination against OPXV. One of these consequences is the emergence of zoonotic OPXV diseases, including (MPXV). The focus of this manuscript is to compare pathology associated with zoonotic OPXV infection in veterinary species and in humans. Efficient recognition of poxvirus lesions and other, more subtle signs of disease in multiple species is critical to prevent further spread of poxvirus infections. Additionally included are a synopsis of the pathology observed in animal models of MPXV infection, the recent spread of MPXV among humans, and a discussion of the potential for this virus to persist in Europe and the Americas.
本综述简要介绍了一种人类特有的正痘病毒（OPXV）对人类的影响历史，回顾了疫苗接种对于根除该疾病的关键作用，并讨论了停止接种OPXV疫苗的后果。其中一个后果是出现了人畜共患的OPXV疾病，包括猴痘病毒（MPXV）。本手稿的重点是比较兽医物种和人类中与人畜共患OPXV感染相关的病理学。有效识别多种物种中的痘病毒病变和其他更细微的疾病迹象对于预防痘病毒感染的进一步传播至关重要。此外，还包括在MPXV感染动物模型中观察到的病理学概述、MPXV最近在人类中的传播情况，以及对该病毒在欧洲和美洲持续存在可能性的讨论。
