血管紧张素转换酶基因多态性研究：一项病例对照研究。
Angiotensin converting enzyme gene polymorphism studies: A case-control study.
作者信息
Saddick Salina Y
机构信息
Department of Biology, Faculty of Science, King Abdulaziz University, P O Box 42671, Jeddah 21551, Saudi Arabia.
出版信息
Saudi J Biol Sci. 2015 May;22(3):327-31. doi: 10.1016/j.sjbs.2014.11.014. Epub 2014 Nov 20.
Abstract
Mild gestational hyperglycemia (MGH) is a very common complication of pregnancy that is characterized by intolerance to glucose. The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism to MGH has been previously reported. In this study, we evaluated the association between ACE polymorphism and the risk of MGH in a Saudi population. We conducted a case-control study in a population of 100 MGH patients and 100 control subjects. ACE gene polymorphism was analyzed by the novel approach of tetraprimer amplification refractory mutation system (ARMS)-polymerase chain reaction (PCR). The frequency of ACE polymorphism was not associated with either alleles or genotypes in MGH patients. Glucose concentration was found to be significantly associated with the MGH group. Our study suggests that ACE genotypes were not associated with ACE polymorphism in a Saudi population.
摘要
轻度妊娠期高血糖（MGH）是一种非常常见的妊娠并发症，其特征为葡萄糖不耐受。先前已有报道血管紧张素转换酶（ACE）插入/缺失（I/D）多态性与MGH之间的关联。在本研究中，我们评估了沙特人群中ACE多态性与MGH风险之间的关联。我们对100例MGH患者和100例对照受试者进行了病例对照研究。采用四引物扩增阻滞突变系统（ARMS）-聚合酶链反应（PCR）的新方法分析ACE基因多态性。MGH患者中ACE多态性的频率与等位基因或基因型均无关联。发现血糖浓度与MGH组显著相关。我们的研究表明，在沙特人群中，ACE基因型与ACE多态性无关。
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