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Meta Gene. 2014 Apr 17;2:299-306. doi: 10.1016/j.mgene.2014.03.001. eCollection 2014 Dec.
2
Postpartum glucose tolerance status 6 to 12 weeks after gestational diabetes mellitus: a Brazilian cohort.妊娠期糖尿病产后6至12周的糖耐量状况：一项巴西队列研究。
Arq Bras Endocrinol Metabol. 2014 Mar;58(2):197-204. doi: 10.1590/0004-2730000003069.
3
Gestational diabetes mellitus prevalence in Maela refugee camp on the Thai-Myanmar border: a clinical report.泰缅边境美拉难民营的妊娠糖尿病流行情况：临床报告。
Glob Health Action. 2014 May 12;7:23887. doi: 10.3402/gha.v7.23887. eCollection 2014.
4
An updated meta-analysis on association between angiotensin I-converting enzyme gene insertion/deletion polymorphism and cancer risk.血管紧张素转换酶基因插入/缺失多态性与癌症风险关联的最新荟萃分析。
Tumour Biol. 2014 Jul;35(7):6567-79. doi: 10.1007/s13277-014-1842-z. Epub 2014 Apr 3.
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Effects of uncomplicated vaginal delivery and epidural analgesia on fetal arterial acid-base parameters at birth in gestational diabetes.妊娠期糖尿病患者阴道分娩和硬膜外镇痛对胎儿出生时动脉酸碱参数的影响。
Diabetes Res Clin Pract. 2014 Mar;103(3):444-51. doi: 10.1016/j.diabres.2013.12.019. Epub 2014 Jan 3.
6
Angiotensin-converting enzyme insertion/deletion polymorphism contributes high risk for chronic kidney disease in Asian male with hypertension--a meta-regression analysis of 98 observational studies.血管紧张素转换酶插入/缺失多态性增加亚洲男性高血压患者慢性肾脏病风险——98 项观察性研究的荟萃回归分析。
PLoS One. 2014 Jan 31;9(1):e87604. doi: 10.1371/journal.pone.0087604. eCollection 2014.
7
ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy.血管紧张素转换酶插入/缺失（I/D）多态性与糖尿病肾病
J Nephropathol. 2012 Oct;1(3):143-51. doi: 10.5812/nephropathol.8109. Epub 2012 Oct 1.
8
Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population.2 型糖尿病相关 SNP 变体与沙特人群肥胖特征的关联。
Mol Biol Rep. 2014 Mar;41(3):1731-40. doi: 10.1007/s11033-014-3022-z. Epub 2014 Jan 17.
9
Angiotensin-converting enzyme gene insertion/deletion polymorphism studies in Asian Indian pregnant women biochemically identifies gestational diabetes mellitus.对亚洲印度裔孕妇进行血管紧张素转换酶基因插入/缺失多态性研究，可通过生化方法识别妊娠期糖尿病。
J Renin Angiotensin Aldosterone Syst. 2014 Dec;15(4):566-71. doi: 10.1177/1470320313502106. Epub 2013 Nov 4.
10
The importance of association between angiotensin-converting enzyme (ACE) Gene I/D polymorphism and diabetic peripheral neuropathy.血管紧张素转换酶（ACE）基因 I/D 多态性与糖尿病周围神经病变的相关性研究。
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血管紧张素转换酶基因多态性研究：一项病例对照研究。

Angiotensin converting enzyme gene polymorphism studies: A case-control study.

作者信息

Saddick Salina Y

机构信息

Department of Biology, Faculty of Science, King Abdulaziz University, P O Box 42671, Jeddah 21551, Saudi Arabia.

出版信息

Saudi J Biol Sci. 2015 May;22(3):327-31. doi: 10.1016/j.sjbs.2014.11.014. Epub 2014 Nov 20.

DOI:10.1016/j.sjbs.2014.11.014
PMID:25972755
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4423719/
Abstract

Mild gestational hyperglycemia (MGH) is a very common complication of pregnancy that is characterized by intolerance to glucose. The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism to MGH has been previously reported. In this study, we evaluated the association between ACE polymorphism and the risk of MGH in a Saudi population. We conducted a case-control study in a population of 100 MGH patients and 100 control subjects. ACE gene polymorphism was analyzed by the novel approach of tetraprimer amplification refractory mutation system (ARMS)-polymerase chain reaction (PCR). The frequency of ACE polymorphism was not associated with either alleles or genotypes in MGH patients. Glucose concentration was found to be significantly associated with the MGH group. Our study suggests that ACE genotypes were not associated with ACE polymorphism in a Saudi population.

摘要

轻度妊娠期高血糖（MGH）是一种非常常见的妊娠并发症，其特征为葡萄糖不耐受。先前已有报道血管紧张素转换酶（ACE）插入/缺失（I/D）多态性与MGH之间的关联。在本研究中，我们评估了沙特人群中ACE多态性与MGH风险之间的关联。我们对100例MGH患者和100例对照受试者进行了病例对照研究。采用四引物扩增阻滞突变系统（ARMS）-聚合酶链反应（PCR）的新方法分析ACE基因多态性。MGH患者中ACE多态性的频率与等位基因或基因型均无关联。发现血糖浓度与MGH组显著相关。我们的研究表明，在沙特人群中，ACE基因型与ACE多态性无关。