Camera Francesca, Paffi Alessandra, Thomas Alex W, Apollonio Francesca, D'Inzeo Guglielmo, Prato Frank S, Liberti Micaela
Department of Information Engineering, Electronics and Telecommunications, "Sapienza" University of Rome Rome, Italy.
Bioelectromagnetics Group, Imaging Program, Lawson Health Research Institute London, ON, Canada.
Front Comput Neurosci. 2015 Apr 28;9:44. doi: 10.3389/fncom.2015.00044. eCollection 2015.
Several experimental results published in the literature showed that weak pulsed magnetic fields affected the response of the central nervous system. However, the specific biological mechanisms that regulate the observed behaviors are still unclear and further scientific investigation is required. In this work we performed simulations on a neuronal network model exposed to a specific pulsed magnetic field signal that seems to be very effective in modulating the brain activity: the Complex Neuroelectromagnetic Pulse (CNP). Results show that CNP can silence the neurons of a feed-forward network for signal intensities that depend on the strength of the bias current, the endogenous noise level and the specific waveforms of the pulses. Therefore, it is conceivable that a neuronal network model responds to the CNP signal with an inhibition of its activity. Further studies on more realistic neuronal networks are needed to clarify if such an inhibitory effect on neuronal tissue may be the basis of the induced analgesia seen in humans and the antinociceptive effects seen in animals when exposed to the CNP.
文献中发表的多项实验结果表明，弱脉冲磁场会影响中枢神经系统的反应。然而，调节所观察到行为的具体生物学机制仍不清楚，需要进一步的科学研究。在这项工作中，我们对暴露于一种特定脉冲磁场信号的神经网络模型进行了模拟，这种信号似乎在调节大脑活动方面非常有效：复合神经电磁脉冲（CNP）。结果表明，对于取决于偏置电流强度、内源性噪声水平和脉冲特定波形的信号强度，CNP可以使前馈网络的神经元沉默。因此，可以想象神经网络模型会以抑制其活动来响应CNP信号。需要对更现实的神经网络进行进一步研究，以阐明对神经元组织的这种抑制作用是否可能是人类暴露于CNP时所观察到的诱导镇痛以及动物所观察到的抗伤害感受作用的基础。
