Avelino Camila Uanne Resende, Cardoso Rafael Marques, Aguiar Suzana Sales de, Silva Mário Jorge Sobreira da
José Alencar Gomes da Silva National Cancer Institute, Rio de Janeiro, Brazil. Multiprofessional Residence Program in Oncology, José Alencar Gomes da Silva National Cancer Institute, Rio de Janeiro, Brazil.
José Alencar Gomes da Silva National Cancer Institute, Rio de Janeiro, Brazil. Chemotherapy Center, Cancer Hospital I, José Alencar Gomes da Silva National Cancer Institute, Rio de Janeiro, Brazil.
J Bras Pneumol. 2015 Mar-Apr;41(2):133-42. doi: 10.1590/S1806-37132015000004367.
Non-small cell lung carcinoma (NSCLC) is the most common type of lung cancer. Most patients are diagnosed at an advanced stage, palliative chemotherapy therefore being the only treatment option. This study was aimed at evaluating the health-related quality of life (HRQoL) of advanced-stage NSCLC patients receiving palliative chemotherapy with carboplatin and paclitaxel.
This was a multiple case study of advanced-stage NSCLC outpatients receiving chemotherapy at a public hospital in Rio de Janeiro, Brazil. The European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire was used in conjunction with its supplemental lung cancer-specific module in order to assess HRQoL.
Physical and cognitive functioning scale scores differed significantly among chemotherapy cycles, indicating improved and worsened HRQoL, respectively. The differences regarding the scores for pain, loss of appetite, chest pain, and arm/shoulder pain indicated improved HRQoL.
Chemotherapy was found to improve certain aspects of HRQoL in patients with advanced-stage NSCLC.
非小细胞肺癌（NSCLC）是最常见的肺癌类型。大多数患者在晚期被诊断出来，因此姑息化疗是唯一的治疗选择。本研究旨在评估接受卡铂和紫杉醇姑息化疗的晚期NSCLC患者的健康相关生活质量（HRQoL）。
这是一项对在巴西里约热内卢一家公立医院接受化疗的晚期NSCLC门诊患者进行的多案例研究。使用欧洲癌症研究与治疗组织核心生活质量问卷及其补充的肺癌特异性模块来评估HRQoL。
化疗周期之间的身体和认知功能量表得分存在显著差异，分别表明HRQoL有所改善和恶化。疼痛、食欲不振、胸痛和手臂/肩部疼痛得分的差异表明HRQoL有所改善。
发现化疗可改善晚期NSCLC患者HRQoL的某些方面。
