热休克蛋白gp96在胆囊癌中的表达及其预后的临床意义。
Expression of heat-shock protein gp96 in gallbladder cancer and its prognostic clinical significance.
作者信息
Chen Yongli, Chen Chuanqi, Ma Chengzhi, Sun Shibo, Zhang Jing, Sun Yan
机构信息
Department of General Surgery, Second Affiliated Hospital of Xingtai Medical College Harbin, China ; Department of General Surgery, Second Affiliated Hospital of Harbin Medical University Harbin, China.
Department of General Surgery, Second Affiliated Hospital of Harbin Medical University Harbin, China.
出版信息
Int J Clin Exp Pathol. 2015 Feb 1;8(2):1946-53. eCollection 2015.
PURPOSE
To detect the expression and prognostic clinical significance of heat-shock protein gp96 (HSP gp96) in gallbladder cancer.
METHODS
Immunohistochemistry was used to detect and compare the rate of HSP gp96 expression in 107 samples of gallbladder cancer, 70 of gallbladder adenoma and 67 of chronic cholecystitis. The association of clinicopathological factors and patients' survival were calculated by univariate and multivariate (Cox proportional hazard regression method) analysis.
RESULTS
The expression positive rate of HSP gp96 was 90.7% (97/107) in gallbladder cancer, 71.4% (50/70) in gallbladder adenoma and 47.76% (32/67) in chronic cholecystitis respectively. The positive rate of HSP gp96 in gallbladder cancer tissues was significantly higher than that in gallbladder adenoma and chronic cholecystitis tissues (P < 0.01). Multivariate and Cox regression analysis showed that positive of HSP gp96 (P = 0.026) expression was an independent poor prognostic predictor in gallbladder cancer.
CONCLUSIONS
HSP gp96-positive expression is closely correlated with poor survival in gallbladder cancer.
目的
检测热休克蛋白gp96（HSP gp96）在胆囊癌中的表达及预后临床意义。
方法
采用免疫组织化学法检测并比较107例胆囊癌、70例胆囊腺瘤和67例慢性胆囊炎组织中HSP gp96的表达率。通过单因素和多因素（Cox比例风险回归法）分析计算临床病理因素与患者生存率的相关性。
结果
胆囊癌中HSP gp96的表达阳性率分别为90.7%（97/107），胆囊腺瘤中为71.4%（50/70），慢性胆囊炎中为47.76%（32/67）。胆囊癌组织中HSP gp96的阳性率显著高于胆囊腺瘤和慢性胆囊炎组织（P < 0.01）。多因素Cox回归分析显示，HSP gp96表达阳性（P = 0.026）是胆囊癌独立的不良预后预测指标。
结论
HSP gp96阳性表达与胆囊癌患者的不良生存密切相关。
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