在结直肠癌中表达增加的一种人类核糖体蛋白信使核糖核酸的鉴定。

Identification of a human ribosomal protein mRNA with increased expression in colorectal tumours.

作者信息

Chester K A, Robson L, Begent R H, Talbot I C, Pringle J H, Primrose L, Macpherson A J, Boxer G, Southall P, Malcolm A D

机构信息

Biochemistry Department, Charing Cross & Westminster Medical School, London, U.K.

出版信息

Biochim Biophys Acta. 1989 Dec 22;1009(3):297-300. doi: 10.1016/0167-4781(89)90119-x.

DOI:10.1016/0167-4781(89)90119-x

PMID:2597680

Abstract

A human ribosomal protein cDNA was selected from a normal colon cDNA library on the basis of overexpression in familial adenomatous polyposis. Nucleotide sequence analysis was used to identify this cDNA as corresponding to the human equivalent of the rat ribosomal protein L31 (HL31). We have quantified the expression of HL31 mRNA in colorectal tumours and found overexpression in 23 out of 23 cases. Our results indicate that HL31 is associated with a malfunction of normal growth regulatory mechanisms in these tumours, and suggest a role for HL31 in proliferation and neoplasia.

摘要

基于在家族性腺瘤性息肉病中的过表达，从正常结肠cDNA文库中筛选出一种人类核糖体蛋白cDNA。通过核苷酸序列分析确定该cDNA对应于大鼠核糖体蛋白L31（HL31）的人类等效物。我们已经对结直肠肿瘤中HL31 mRNA的表达进行了定量，发现23例病例中有23例过表达。我们的结果表明，HL31与这些肿瘤中正常生长调节机制的功能障碍有关，并提示HL31在增殖和肿瘤形成中发挥作用。