用于原位水凝胶形成的半胱氨酸修饰透明质酸的改进合成方法。
Improved method for synthesis of cysteine modified hyaluronic acid for in situ hydrogel formation.
作者信息
Zhang Xin, Sun Pengcheng, Huangshan Lingzi, Hu Bi-Huang, Messersmith Phillip B
机构信息
Key Laboratory of Tropical Biological Resources of Ministry of Education, College of Oceanography, Hainan University, Haikou, Hainan Province 570228, China.
出版信息
Chem Commun (Camb). 2015 Jun 14;51(47):9662-5. doi: 10.1039/c5cc02367j.
Abstract
We developed a new strategy for the functionalization of hyaluronic acid by chemical modification of its C-6 hydroxyl groups through an ether bond to obtain a cysteine-hyaluronic acid conjugate. This conjugate is suitable to prepare injectable and in situ formed hydrogels cross-linked by native chemical ligation and Michael addition under mild conditions.
摘要
我们开发了一种新策略，通过将透明质酸的C-6羟基通过醚键进行化学修饰来实现其功能化，从而获得半胱氨酸-透明质酸共轭物。这种共轭物适合制备在温和条件下通过天然化学连接和迈克尔加成交联的可注射且原位形成的水凝胶。
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