Maj M
Department of Psychiatry, First Medical School, University of Naples, Italy.
Br J Psychiatry. 1989 May;154:640-3. doi: 10.1192/bjp.154.5.640.
A family study was carried out in two groups of patients fulfilling RDC for schizoaffective disorder: in one, a full affective and a full schizophrenic syndrome were simultaneously present; in the other, affective and schizophrenic features appeared within a polymorphic and rapidly changing clinical picture, with depersonalization/derealization and/or confusion. In the first-degree relatives of patients of the former group, the risk of major psychiatric disorders was not significantly different from that of relatives of schizophrenics, whereas in the first-degree relatives of patients of the latter group a low risk for both schizophrenia and major affective disorders, and a relatively high risk for schizoaffective disorders, were observed.
对两组符合精神分裂情感性障碍研究诊断标准（RDC）的患者进行了一项家族研究：一组患者同时存在完全的情感综合征和完全的精神分裂症综合征；另一组患者的情感和精神分裂症特征出现在多形性且快速变化的临床症状中，伴有人格解体/现实解体和/或意识模糊。在前一组患者的一级亲属中，重大精神障碍的风险与精神分裂症患者亲属的风险无显著差异，而在后一组患者的一级亲属中，观察到精神分裂症和重大情感障碍的风险较低，精神分裂情感性障碍的风险相对较高。
