Li Wenping, Shi Jingshan, Papa Fabrizio, Maggi Filippo, Chen Xiuping
a Key Lab for Pharmacology of Ministry of Education, Department of Pharmacology , Zunyi Medical College , Zunyi , P.R. China.
b School of Science and Technology, University of Camerino , Italy.
Nat Prod Res. 2016;30(10):1162-5. doi: 10.1080/14786419.2015.1041139. Epub 2015 May 15.
Isofuranodiene is a natural sesquiterpene rich occurring in Smyrnium olusatrum, a forgotten culinary herb which was marginalised after the domestication of the improved form of celery. Our recent data showed that isofuranodiene inhibited the proliferation and induced apoptosis in cancer cells. In this study, we investigated its protective effect on d-galactosamine/lipopolysacchride (GalN/LPS)-induced liver injury in SD rats. Oral administration of isofuranodiene (20 and 50 mg/kg) dramatically inhibited GalN/LPS-induced serum elevation of aspartate aminotransferase, alanine aminotransferase and malondialdehyde levels, and significantly ameliorated liver injury as evidenced by the histological improvement in H&E staining. Furthermore, isofuranodiene treatment significantly inhibited GalN/LPS-induced mRNA expression of IL-1β, IL-6 and inducible nitric oxide synthase in liver tissues. The results from this study showed that isofuranodiene protects GalN/LPS-induced liver injury in SD rats and suggested that it may be a potential functional food ingredient for the prevention and treatment of liver diseases.
异呋喃二烯是一种天然倍半萜，大量存在于阔叶水芹中，阔叶水芹是一种被遗忘的烹饪香草，在改良芹菜品种驯化后被边缘化。我们最近的数据表明，异呋喃二烯可抑制癌细胞增殖并诱导其凋亡。在本研究中，我们调查了其对d-半乳糖胺/脂多糖（GalN/LPS）诱导的SD大鼠肝损伤的保护作用。口服异呋喃二烯（20和50 mg/kg）可显著抑制GalN/LPS诱导的血清天冬氨酸转氨酶、丙氨酸转氨酶和丙二醛水平升高，并显著改善肝损伤，苏木精-伊红（H&E）染色的组织学改善证明了这一点。此外，异呋喃二烯处理可显著抑制GalN/LPS诱导的肝组织中白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和诱导型一氧化氮合酶的mRNA表达。本研究结果表明，异呋喃二烯可保护GalN/LPS诱导的SD大鼠肝损伤，并表明它可能是预防和治疗肝脏疾病的一种潜在功能性食品成分。
