Grucza Richard A, Hur Michael, Agrawal Arpana, Krauss Melissa J, Plunk Andrew D, Cavazos-Rehg Patricia A, Chaloupka Frank J, Bierut Laura J
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Drug Alcohol Depend. 2015 Jul 1;152:68-72. doi: 10.1016/j.drugalcdep.2015.04.014. Epub 2015 Apr 30.
Previous research has suggested that medical marijuana policies lead to reductions in suicide rates. In this study, we further investigate the association between these policies and within-state changes in suicide risk.
Data on suicide deaths (n=662,993) from the National Vital Statistics System Multiple Cause of Death files were combined with living population data. Fixed-effects regression methods were employed to control for state differences in suicide rates and national and state secular trends. Analyses extended prior research that suggested a protective effect of medical marijuana policies by incorporating newer data and additional covariates.
After adjustment for race/ethnicity, tobacco control policies, and other covariates, we found no association between medical marijuana policy and suicide risk in the population ages 15 and older (OR=1.000; 95% CI: 0.956, 1.045; p=0.98), among men overall (OR=0.996; 95% CI: 0.951, 1.043; p=0.87) or for any other age-by-sex groups.
We find no statistically significant association between medical marijuana policy and suicide risk. These results contradict prior analyses which did not control for race/ethnicity and certain state characteristics such as tobacco control policies. Failure to control for these factors in future analyses would likely bias estimates of the associations between medical marijuana policy and health outcomes.
先前的研究表明，医用大麻政策可降低自杀率。在本研究中，我们进一步调查这些政策与州内自杀风险变化之间的关联。
将来自国家生命统计系统多死因档案的自杀死亡数据（n = 662,993）与常住人口数据相结合。采用固定效应回归方法来控制各州自杀率以及全国和各州长期趋势的差异。分析通过纳入更新数据和其他协变量，扩展了先前表明医用大麻政策具有保护作用的研究。
在对种族/族裔、烟草控制政策和其他协变量进行调整后，我们发现15岁及以上人群中，医用大麻政策与自杀风险之间无关联（OR = 1.000；95% CI：0.956, 1.045；p = 0.98），总体男性中（OR = 0.996；95% CI：0.951, 1.043；p = 0.87）或其他任何年龄 - 性别组中均无关联。
我们发现医用大麻政策与自杀风险之间无统计学上的显著关联。这些结果与先前未控制种族/族裔和某些州特征（如烟草控制政策）的分析结果相矛盾。未来分析中若未控制这些因素，可能会使医用大麻政策与健康结果之间关联的估计产生偏差。
