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高危患者的开放性主动脉弓置换术:金标准。

Open aortic arch replacement in high-risk patients: the gold standard.

作者信息

Iafrancesco Mauro, Ranasinghe Aaron M, Dronavalli Vamsidhar, Adam Donald J, Claridge Martin W, Riley Peter, McCafferty Ian, Mascaro Jorge G

机构信息

Department of Cardiothoracic Surgery/Thoracic Aortic Multidisciplinary Team, Queen Elizabeth University Hospital NHS Foundation Trust, Birmingham, UK Vascular Surgery Department/Thoracic Aortic Multidisciplinary Team, Heart of England NHS Foundation Trust, Birmingham, UK.

Department of Cardiothoracic Surgery/Thoracic Aortic Multidisciplinary Team, Queen Elizabeth University Hospital NHS Foundation Trust, Birmingham, UK.

出版信息

Eur J Cardiothorac Surg. 2016 Feb;49(2):646-51; discussion 651. doi: 10.1093/ejcts/ezv149. Epub 2015 May 15.

Abstract

OBJECTIVES

Open total aortic arch replacement (TAR) in high-risk patients is considered by some to be associated with a prohibitively perioperative risk. Recent reports describe hybrid techniques to treat this group. We reviewed our outcomes of open surgery in a 'high-risk' group of patients.

METHODS

All patients who underwent open TAR between 2000 and 2013 were identified from our prospectively maintained database. Patients comparable with the ones who underwent hybrid repair in previous studies (logistic EuroSCORE between 20 and 60 without intervention on the aortic root or on the mitral/tricuspid valve) were selected for analysis.

RESULTS

Fifty-eight patients were identified. Median logistic EuroSCORE was 27.4 (range 20-57) and median age was 76 years (34.5% male). There were 11 resternotomies (18.9%) and 20 procedures were urgent/emergency (34.5%). Preoperative comorbidities included chronic obstructive pulmonary disease (31%), coronary artery disease (22.4%), peripheral vascular disease (48.3%), previous stroke (5.2%), previous myocardial infarction (3.4%) and left ventricular dysfunction (12%). Concomitant procedures included aortic valve replacement/resuspension (58.7%), coronary artery bypass grafting (22.4%), open descending aorta replacement (10.3%) and frozen elephant trunk (19%). Overall in-hospital mortality, permanent stroke and spinal cord injury rate were 6.9, 1.7 and 0%, respectively. There were no deaths or stroke in the elective group. One-year, 5-year and 10-year estimates of survival were 82.7, 70.0 and 37.8%, respectively.

CONCLUSIONS

Open TAR can be performed with low mortality and morbidity and excellent long-term results even in high-risk patients. Total endovascular repair may represent an option for patients not suitable for open surgery.

摘要

目的

一些人认为,高危患者的开放性全主动脉弓置换术(TAR)围手术期风险过高。近期报告描述了治疗该类患者的杂交技术。我们回顾了一组“高危”患者的开放手术结果。

方法

从我们前瞻性维护的数据库中识别出2000年至2013年间接受开放性TAR的所有患者。选择与既往研究中接受杂交修复的患者(逻辑欧洲心脏手术风险评估系统评分在20至60之间,且未对主动脉根部或二尖瓣/三尖瓣进行干预)具有可比性的患者进行分析。

结果

共识别出58例患者。逻辑欧洲心脏手术风险评估系统评分中位数为27.4(范围20 - 57),年龄中位数为76岁(男性占34.5%)。有11例再次胸骨切开术(18.9%),20例手术为急诊/紧急手术(34.5%)。术前合并症包括慢性阻塞性肺疾病(31%)、冠状动脉疾病(22.4%)、外周血管疾病(48.3%)、既往卒中(5.2%)、既往心肌梗死(3.4%)和左心室功能障碍(12%)。同期手术包括主动脉瓣置换/悬吊(58.7%)、冠状动脉旁路移植术(22.4%)、开放性降主动脉置换术(10.3%)和冰冻象鼻手术(19%)。总体住院死亡率、永久性卒中率和脊髓损伤率分别为6.9%、1.7%和0%。择期手术组无死亡或卒中病例。1年、5年和10年生存率估计分别为82.7%、70.0%和37.8%。

结论

即使是高危患者,开放性TAR也能以低死亡率和发病率以及良好的长期效果进行。完全血管腔内修复可能是不适合开放手术患者的一种选择。

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