Villringer A, Haberl R L, Dirnagl U, Anneser F, Verst M, Einhäupl K M
Department of Neurology, Ludwig-Maximilians-University Munich, F.R.G.
Brain Res. 1989 Dec 11;504(1):159-60. doi: 10.1016/0006-8993(89)91616-8.
We demonstrate the feasibility of using confocal laser microscopy (CLM) to study the microcirculation on the rat brain surface. Using a closed cranial window model in vivo, microvessels in the size range of capillaries (8 microns) and dynamic events were observed through an intact dura. This study is the first step in the development of a system which simultaneously monitors vascular and metabolic processes using CLM.
我们证明了使用共聚焦激光显微镜（CLM）研究大鼠脑表面微循环的可行性。在体内使用封闭颅骨窗模型，通过完整的硬脑膜观察到大小在毛细血管范围（8微米）的微血管和动态事件。本研究是开发一个使用CLM同时监测血管和代谢过程的系统的第一步。
