Prema Asokan, Janakiraman Udaiyappan, Manivasagam Thamilarasan, Thenmozhi Arokiasamy Justin
Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608002, Tamilnadu, India.
Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608002, Tamilnadu, India.
Neurosci Lett. 2015 Jul 10;599:12-9. doi: 10.1016/j.neulet.2015.05.024. Epub 2015 May 14.
Parkinson's disease (PD) is the second most common neurodegenerative disorder that mainly affects the movement of the aged populations. Lycopene is a carotenoid with unique pharmacological properties and its efficacy on experimental Hunginton's disease and brain ischemia has shown intense neuroprotective effects. The present study was aimed to explore the neuroprotective effect of lycopene against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced PD mice. Administration of lycopene (5, 10 and 20 mg/kg/day orally) protected MPTP induced depletion of striatal dopamine (DA) and its metabolites in a dose dependent manner. It also attenuated MPTP-induced oxidative stress and motor abnormalities seen in PD mice. Our western blot studies showed that treatment with lycopene reversed MPTP induced apoptosis may be due to its antioxidant and antiapoptotic properties. As to conclude, lycopene reverses neurochemical deficts, oxidative stress, apoptosis and physiological abnormalities in PD mice and offer promise strategy in the treatment of this neurodegenerative disease.
帕金森病（PD）是第二常见的神经退行性疾病，主要影响老年人群的运动。番茄红素是一种具有独特药理特性的类胡萝卜素，其对实验性亨廷顿病和脑缺血的疗效已显示出强烈的神经保护作用。本研究旨在探讨番茄红素对1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的帕金森病小鼠的神经保护作用。口服给予番茄红素（5、10和20mg/kg/天）以剂量依赖性方式保护MPTP诱导的纹状体多巴胺（DA）及其代谢产物的耗竭。它还减轻了MPTP诱导的帕金森病小鼠的氧化应激和运动异常。我们的蛋白质印迹研究表明，番茄红素治疗可逆转MPTP诱导的细胞凋亡，这可能归因于其抗氧化和抗凋亡特性。总之，番茄红素可逆转帕金森病小鼠的神经化学缺陷、氧化应激、细胞凋亡和生理异常，并为治疗这种神经退行性疾病提供了有前景的策略。
