Denning W Matt, Winward Jason G, Pardo Michael Becker, Hopkins J Ty, Seeley Matthew K
Department of Health Promotion and Human Performance, Weber State University , Ogden, UT, USA.
Department of Exercise Sciences, Brigham Young University , Provo, UT, USA.
J Sports Sci Med. 2015 May 8;14(2):290-6. eCollection 2015 Jun.
Although obesity is associated with osteoarthritis, it is unclear whether body weight (BW) independently affects articular cartilage catabolism (i.e., independent from physiological factors that also accompany obesity). The primary purpose of this study was to evaluate the independent effect of BW on articular cartilage catabolism associated with walking. A secondary purpose was to determine how decreased BW influenced cardiovascular response due to walking. Twelve able-bodied subjects walked for 30 minutes on a lower-body positive pressure treadmill during three sessions: control (unadjusted BW), +40%BW, and -40%BW. Serum cartilage oligomeric matrix protein (COMP) was measured immediately before (baseline) and after, and 15 and 30 minutes after the walk. Heart rate (HR) and rate of perceived exertion (RPE) were measured every three minutes during the walk. Relative to baseline, average serum COMP concentration was 13% and 5% greater immediately after and 15 minutes after the walk. Immediately after the walk, serum COMP concentration was 14% greater for the +40%BW session than for the -40%BW session. HR and RPE were greater for the +40%BW session than for the other two sessions, but did not differ between the control and -40%BW sessions. BW independently influences acute articular cartilage catabolism and cardiovascular response due to walking: as BW increases, so does acute articular cartilage catabolism and cardiovascular response. These results indicate that lower-body positive pressure walking may benefit certain individuals by reducing acute articular cartilage catabolism, due to walking, while maintaining cardiovascular response. Key pointsWalking for 30 minutes with adjustments in body weight (normal body weight, +40% and -40% body weight) significantly influences articular cartilage catabolism, measured via serum COMP concentration.Compared to baseline levels, walking with +40% body weight and normal body weight both elicited significant increases in articular cartilage catabolism, while walking with -40% body weight did not.Cardiovascular response (HR and RPE) was not significantly different during walking with normal body weight and when compared to walking with -40% body weight.
尽管肥胖与骨关节炎相关，但体重（BW）是否独立影响关节软骨分解代谢（即独立于肥胖伴随的生理因素）尚不清楚。本研究的主要目的是评估体重对与行走相关的关节软骨分解代谢的独立影响。次要目的是确定体重减轻如何影响行走时的心血管反应。12名身体健全的受试者在下肢正压跑步机上进行了三个阶段的30分钟行走：对照组（未调整体重）、+40%BW和-40%BW。在行走前（基线）、行走后、行走后15分钟和30分钟立即测量血清软骨寡聚基质蛋白（COMP）。在行走过程中每三分钟测量一次心率（HR）和自觉用力程度（RPE）。相对于基线，行走后立即和行走后15分钟时，血清COMP平均浓度分别高出13%和5%。行走后立即测量，+40%BW组的血清COMP浓度比-40%BW组高出14%。+40%BW组的HR和RPE高于其他两组，但对照组和-40%BW组之间无差异。体重独立影响与行走相关的急性关节软骨分解代谢和心血管反应：随着体重增加，急性关节软骨分解代谢和心血管反应也增加。这些结果表明，下肢正压行走可能通过减少因行走导致的急性关节软骨分解代谢，同时维持心血管反应，而使某些个体受益。要点通过调整体重（正常体重、+40%和-40%体重）进行30分钟行走，显著影响通过血清COMP浓度测量的关节软骨分解代谢。与基线水平相比，+40%体重行走和正常体重行走均引起关节软骨分解代谢显著增加，而-40%体重行走则未引起。正常体重行走时的心血管反应（HR和RPE）与-40%体重行走相比无显著差异。
