Li Na, Wang Chuan, Jia LiXin, Du Jie
Capital Medical University Affiliated Beijing Anzhen Hospital, Anzhenli, Chaoyang District, Beijing, 100029 China ; Lung and Vessel Diseases, Beijing Research Institute of Heart, Beijing, 100029 China.
Capital Medical University Affiliated Beijing Anzhen Hospital, Anzhenli, Chaoyang District, Beijing, 100029 China.
Regen Med Res. 2014 Apr 2;2(1):6. doi: 10.1186/2050-490X-2-6. eCollection 2014 Dec.
The human heart has limited regenerative capacity, which makes the reparative response after the cardiac infarction quite challenging. During the last decade, stem cells have become promising candidates for heart repair, owing to their potent differentiation capacity and paracrine cytokine secretion. Among the different types of stem cells, mesenchymal stem cells have high proliferative potential and secrete numerous cytokines, growth factors, and microRNAs. The paracrine cytokines play important roles in cardiac regeneration, neovascularization, anti-apoptosis, and anti-remodeling mechanisms, among others. This review summarizes the cytokines secreted by stem cells and their relative signaling pathways, which represent key mechanisms for heart regeneration and may serve as a promising future therapeutic strategy for myocardial infarction patients.
人类心脏的再生能力有限，这使得心肌梗死后的修复反应颇具挑战性。在过去十年中，干细胞因其强大的分化能力和旁分泌细胞因子的分泌，成为心脏修复的有希望的候选者。在不同类型的干细胞中，间充质干细胞具有高增殖潜力，并分泌多种细胞因子、生长因子和微小RNA。旁分泌细胞因子在心脏再生、新血管形成、抗凋亡和抗重塑机制等方面发挥着重要作用。本综述总结了干细胞分泌的细胞因子及其相关信号通路，这些代表了心脏再生的关键机制，可能成为心肌梗死患者未来有前景的治疗策略。
