Huang Ya-Fang, Tok Teck-Siang, Lu Chin-Li, Ko Hsing-Ching, Chen Min-Yu, Chen Solomon Chih-Cheng
Department of Clinical Laboratory, Pingtung Christian Hospital, Pingtung City, Taiwan.
Department of Pediatrics, Pingtung Christian Hospital, Pingtung City, Taiwan.
Pediatr Neonatol. 2015 Dec;56(6):386-92. doi: 10.1016/j.pedneo.2015.02.003. Epub 2015 Apr 18.
Being overweight has been considered to be a risk factor of iron deficiency (ID). The objective of this study was to examine the relationship between being overweight and body iron status among Taiwanese adolescents.
A total of 2099 adolescents (1327 female) aged 12-19 years from four middle schools and one college in southern Taiwan participated in this study. Data on sex, age, body weight, height, hemoglobin concentration, plasma ferritin (PF), and serum iron (SI) levels were collected. According to the age- and sex-specific body mass index (BMI) percentiles, the participants were divided into four weight groups: underweight (<5(th) percentile), normal weight (5-84(th) percentile), overweight (85-94(th) percentile), and obese (≥95(th) percentile). A multivariate logistic regression model was used to estimate the odds ratio (OR) and the 95% confidence interval (CI) for each factor.
The correlation coefficients of linear regression were positive for BMI-hemoglobin and BMI-PF, but negative for BMI-SI. Compared with the normal-weight group, the obese group had a lower risk of PF level <15 μg/L with an OR (95% CI) of 0.51 (0.30-0.87) but a higher risk of SI <60 μg/dL with an OR (95% CI) of 1.78 (1.34-2.37). The percentages of low PF declined as BMI increased, but the percentages of low SI rose, from underweight to obesity groups.
The relationship between being overweight and depleted iron store depends on which indicator is used to define the iron deficiency. Being overweight or obese would not be a risk factor of ID in adolescents, if ID were defined by PF rather than SI level.
超重被认为是缺铁（ID）的一个风险因素。本研究的目的是探讨台湾青少年超重与机体铁状态之间的关系。
来自台湾南部四所中学和一所大学的2099名12 - 19岁青少年（1327名女性）参与了本研究。收集了性别、年龄、体重、身高、血红蛋白浓度、血浆铁蛋白（PF）和血清铁（SI）水平的数据。根据年龄和性别特异性体重指数（BMI）百分位数，参与者被分为四个体重组：体重过轻（<第5百分位数）、正常体重（第5 - 84百分位数）、超重（第85 - 94百分位数）和肥胖（≥第95百分位数）。使用多变量逻辑回归模型估计每个因素的比值比（OR）和95%置信区间（CI）。
BMI与血红蛋白以及BMI与PF的线性回归相关系数为正，但BMI与SI的线性回归相关系数为负。与正常体重组相比，肥胖组PF水平<15μg/L的风险较低，OR（95%CI）为0.51（0.30 - 0.87），但SI<60μg/dL的风险较高，OR（95%CI）为1.78（1.34 - 2.37）。从体重过轻组到肥胖组，低PF的百分比随着BMI的增加而下降，但低SI的百分比上升。
超重与铁储存耗竭之间的关系取决于用于定义缺铁的指标。如果用PF而非SI水平来定义缺铁，超重或肥胖在青少年中不会是缺铁的风险因素。
