Ge Isabell, Rudolph Anja, Shivappa Nitin, Flesch-Janys Dieter, Hébert James R, Chang-Claude Jenny
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany; Faculty of Medicine, Heidelberg University, Heidelberg, Baden-Württemberg D-69120, Germany.
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
Breast. 2015 Aug;24(4):491-6. doi: 10.1016/j.breast.2015.04.012. Epub 2015 May 16.
Unhealthy dietary habits can increase the risk for serious medical conditions, such as cancer, yet the association between diet and breast cancer remains unclear. We investigated whether individual diets based on their inflammatory potential are associated with postmenopausal breast cancer risk by employing an energy-adjusted dietary inflammation index. In a German population-based case-control study, 2887 postmenopausal breast cancer patients (aged 50-74 years, first diagnosed between 2002 and 2005) and 5512 healthy age-matched controls provided information on dietary habits for the year prior to diagnosis (cases) or recruitment (controls) using a 176-items food frequency questionnaire. Associations between the energy-adjusted dietary inflammation index (E-DII) score (both as continuous variable and in quintiles) and risk for breast cancer were assessed using conditional logistic regression adjusted for potential confounders. No significant associations between the E-DII score and postmenopausal breast cancer risk were observed (adjusted OR Q5 vs Q1: 1.01, 95% CI: 0.86-1.17). Associations did not differ by estrogen receptor/progesterone receptor status (ER + PR+: adjusted OR Q5 vs Q1: 1.06, 95% CI: 0.88-1.27; ER + or PR+: OR Q5 vs Q1: 1,07, 95% CI: 0.79-1.45; ER-PR-: OR Q5 vs Q1: 0.87 95% CI: 0.63-1.20). Our results regarding E-DII are consistent with previous studies reporting a lack of association between C-reactive protein, a marker of systemic inflammation, and postmenopausal breast cancer risk. The findings may reflect a real absence of association between dietary inflammatory potential and postmenopausal cancer risk or an underestimation of association due to recall bias. Further investigation is warranted in cohort studies.
不健康的饮食习惯会增加患严重疾病（如癌症）的风险，但饮食与乳腺癌之间的关联仍不明确。我们通过采用能量调整膳食炎症指数，研究了基于炎症潜能的个体饮食与绝经后乳腺癌风险之间的关系。在一项基于德国人群的病例对照研究中，2887名绝经后乳腺癌患者（年龄50 - 74岁，首次诊断时间为2002年至2005年）和5512名年龄匹配的健康对照者，使用一份包含176项内容的食物频率问卷，提供了诊断前一年（病例组）或招募时（对照组）的饮食习惯信息。使用针对潜在混杂因素进行调整的条件逻辑回归，评估能量调整膳食炎症指数（E-DII）得分（作为连续变量和五分位数）与乳腺癌风险之间的关联。未观察到E-DII得分与绝经后乳腺癌风险之间存在显著关联（调整后的OR，Q5与Q1相比：1.01，95%CI：0.86 - 1.17）。雌激素受体/孕激素受体状态不同，关联也无差异（ER + PR +：调整后的OR，Q5与Q1相比：1.06，95%CI：0.88 - 1.27；ER + 或PR +：OR，Q5与Q1相比：1.07，95%CI：0.79 - 1.45；ER - PR -：OR，Q5与Q1相比：0.87，95%CI：0.63 - 1.20）。我们关于E-DII的结果与之前的研究一致，这些研究报告全身性炎症标志物C反应蛋白与绝经后乳腺癌风险之间缺乏关联。这些发现可能反映出膳食炎症潜能与绝经后癌症风险之间确实不存在关联，或者由于回忆偏倚导致关联被低估。队列研究有必要进一步开展调查。
