HIV-1感染中针对包膜糖蛋白的抗体反应。
Antibody responses to envelope glycoproteins in HIV-1 infection.
作者信息
Burton Dennis R, Mascola John R
机构信息
1] Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA. [2] International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, USA. [3] Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, USA. [4] Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, Massachusetts, USA.
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
Nat Immunol. 2015 Jun;16(6):571-6. doi: 10.1038/ni.3158.
Antibody responses to the HIV-1 envelope glycoproteins can be classified into three groups. Binding but non-neutralizing responses are directed to epitopes that are expressed on isolated envelope glycoproteins but not on the native envelope trimer found on the surface of virions and responsible for mediating the entry of virus into target cells. Strain-specific responses and broadly neutralizing responses, in contrast, target epitopes that are expressed on the native trimer, as revealed by recently resolved structures. The past few years have seen the isolation of many broadly neutralizing antibodies of remarkable potency that have shown prophylactic and therapeutic activities in animal models. These antibodies are helping to guide rational vaccine design and therapeutic strategies for HIV-1.
对HIV-1包膜糖蛋白的抗体反应可分为三类。结合但不具有中和作用的反应针对的是在分离的包膜糖蛋白上表达的表位，但在病毒体表面发现的天然包膜三聚体上不表达，而天然包膜三聚体负责介导病毒进入靶细胞。相比之下，菌株特异性反应和广泛中和反应针对的是天然三聚体上表达的表位，最近解析的结构揭示了这一点。在过去几年中，已经分离出许多具有显著效力的广泛中和抗体，这些抗体在动物模型中显示出预防和治疗活性。这些抗体有助于指导针对HIV-1的合理疫苗设计和治疗策略。
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