Cornish-Bowden A
Centre de Biochimie et de Biologie Moléculaire, Centre National de la Recherche Scientifique, Marseille, France.
J Theor Biol. 1989 Feb 22;136(4):365-77. doi: 10.1016/s0022-5193(89)80154-7.
The claim by Savageau et al. (1987 a, b, Math. Biosci. 86, 127-145, 147-167) that the theory of metabolic control associated with Kacser & Burns (1973, Symp. Soc. Exp. Biol. 27, 65-104) and with Heinrich & Rapoport (1974, Eur. J. Biochem. 42, 89-102) is no more than a special case of the biochemical systems theory of Savageau and colleagues is examined. It is shown to be based on a misconception of the objectives and assumptions of metabolic control theory. In particular, the control and elasticity coefficients that play a central role in metabolic control theory are not constants and cannot be treated as constants. Consequently they cannot in general be equated with the kinetic orders that appear in biochemical systems theory, though they do correspond at the point where the two theories are tangential to one another.
萨维奥等人（1987a、b，《数学生物学》86卷，第127 - 145页、147 - 167页）声称，与凯瑟和伯恩斯（1973年，《实验生物学学会专题讨论会》27卷，第65 - 104页）以及海因里希和拉波波特（1974年，《欧洲生物化学杂志》42卷，第89 - 102页）相关的代谢控制理论只不过是萨维奥及其同事的生化系统理论的一个特例。本文对此进行了审视。结果表明，该声称基于对代谢控制理论目标和假设的误解。特别是，在代谢控制理论中起核心作用的控制系数和弹性系数并非常数，也不能被当作常数来处理。因此，尽管它们在两种理论相切的点处相对应，但一般而言，不能将它们与生化系统理论中出现的动力学级数等同起来。
