Mendy A, Vieira E R, Albatineh A N, Gasana J
Department of Epidemiology,College of Public Health,University of Iowa,Iowa City,Iowa,USA.
Department of Physical Therapy,Florida International University,Miami,Florida,USA.
Parasitology. 2015 Aug;142(9):1221-7. doi: 10.1017/S0031182015000505. Epub 2015 May 20.
Toxoplasma gondii (T. gondii) infects one-third of the world population, but its association with cognitive functions in school-aged children is unclear. We examined the relationship between Toxoplasma seropositivity and neuropsychological tests scores (including math, reading, visuospatial reasoning and verbal memory) in 1755 school-aged children 12-16 years old who participated to the Third National Health and Nutrition Examination Survey, using multiple linear regressions adjusted for covariates. Toxoplasma seroprevalence was 7·7% and seropositivity to the parasite was associated with lower reading skills (regression coefficient [β] = -5·86, 95% confidence interval [CI]: -11·11, -0·61, P = 0·029) and memory capacities (β = -0·86, 95% CI: -1·58, -0·15, P = 0·017). The interaction between T. gondii seropositivity and vitamin E significantly correlated with memory scores. In subgroup analysis, Toxoplasma-associated memory impairment was worse in children with lower serum vitamin E concentrations (β = -1·61, 95% CI: -2·44, -0·77, P < 0·001) than in those with higher values (β = -0·12, 95% CI: -1·23, 0·99, P = 0·83). In conclusion, Toxoplasma seropositivity may be associated with reading and memory impairments in school-aged children. Serum vitamin E seems to modify the relationship between the parasitic infection and memory deficiency.
弓形虫感染了全球三分之一的人口，但其与学龄儿童认知功能之间的关联尚不清楚。我们对参加第三次全国健康与营养检查调查的1755名12至16岁的学龄儿童进行了研究，通过多元线性回归分析了弓形虫血清阳性与神经心理测试分数（包括数学、阅读、视觉空间推理和言语记忆）之间的关系，并对协变量进行了调整。弓形虫血清阳性率为7.7%，寄生虫血清阳性与较低的阅读技能（回归系数[β]= -5.86，95%置信区间[CI]：-11.11，-0.61，P = 0.029）和记忆能力（β = -0.86，95% CI：-1.58，-0.15，P = 0.017）相关。弓形虫血清阳性与维生素E之间的相互作用与记忆分数显著相关。在亚组分析中，血清维生素E浓度较低的儿童中，弓形虫相关的记忆损害比血清维生素E浓度较高的儿童更严重（β = -1.61，95% CI：-2.44，-0.77，P < 0.001）（β = -0.12，95% CI：-1.23，0.99，P = 0.83）。总之，弓形虫血清阳性可能与学龄儿童的阅读和记忆损害有关。血清维生素E似乎改变了寄生虫感染与记忆缺陷之间的关系。
