West Virginia University, Department of Dental Practice and Rural Health, School of Dentistry, 104a Health Sciences Addition, PO Box 9415, Morgantown, WV 26506, United States of America.
West Virginia University, Department of Dental Research, School of Dentistry, 106a Health Sciences Addition, PO Box 9448, Morgantown, WV 26506, United States of America.
Parasitol Int. 2020 Oct;78:102123. doi: 10.1016/j.parint.2020.102123. Epub 2020 May 13.
Toxoplasma gondii (T. gondii) causes chronic, latent infections of global concern. Its subclinical influence on behavior and cognition are poorly understood. The objective of this research is to determine the relationship of T. gondii IgG with cognition using National Health and Nutrition Examination Survey data, 2013-2014 in older adults ≥60 years. A composite cognitive function score was created by adding the scores of the memory test, language/verbal fluency, and working memory test. T. gondii IgG was dichotomized at <33 IU/mL (negative) and ≥33 IU/mL (positive). There were 19.2% of the participants who were T. gondii IgG. The memory function and language/verbal fluency subtests failed to reach significance; however, the difference in the working memory test was significant. In the multivariable ordinal logistic regression analysis, controlling for potential confounders, the odds of cognitive function scores decreasing in quartiles among people with positive vs. negative T. gondii IgG are 1.55 (95% CI: 1.08, 2.21; p = .0170). Establishing an evidence base for the association of T. gondii IgG and cognition is complex, but essential.
刚地弓形虫（Toxoplasma gondii）引起具有全球关注的慢性、潜伏性感染。其对行为和认知的亚临床影响尚未被充分了解。本研究旨在利用 2013-2014 年国家健康与营养调查（National Health and Nutrition Examination Survey，NHANES）数据，确定老年人（≥60 岁）中 T. gondii IgG 与认知的关系。通过记忆测试、语言/言语流畅性和工作记忆测试的得分相加，创建了一个综合认知功能评分。将 T. gondii IgG 分为<33 IU/mL（阴性）和≥33 IU/mL（阳性）。有 19.2%的参与者 T. gondii IgG 呈阳性。记忆功能和语言/言语流畅性测试亚组未达到显著性差异；然而，工作记忆测试的差异具有显著性。在多变量有序逻辑回归分析中，控制潜在混杂因素后，T. gondii IgG 阳性者的认知功能评分在四分位组中下降的几率是 T. gondii IgG 阴性者的 1.55 倍（95%置信区间：1.08，2.21；p=0.0170）。建立 T. gondii IgG 与认知之间关联的证据基础是复杂的，但也是必要的。
