Department of Thoracic Surgery & Tumor Research Institute, Tianjin Union Medicine Centre, Tianjin, China.
Department of Microbiology & Infectious Disease Center, School of Basic Medical Science, Peking University Health Science Center, Beijing, China.
Cancer Gene Ther. 2015 Jun;22(6):291-301. doi: 10.1038/cgt.2015.19. Epub 2015 May 22.
MicroRNAs (miRNAs), which are small single-stranded RNA molecules composed of 18-23 nucleotides, act as oncogenes or tumor suppressor genes playing important roles in tumor formation, infiltration and metastasis. Subsequently, miRNAs expression contributes to cancer diagnosis and prognosis. Gastric cancer currently has high morbidity and mortality among all malignant tumors, yet it lacks early specific diagnostic markers and effective treatments. In gastric cancer, many studies have detected abnormal expression forms of miRNAs and confirmed their involvement in its tumorigenesis, progression, invasion and metastasis. They may become valuable diagnostic markers and therapeutic targets for gastric cancer. Studying the role of miRNAs in gastric cancer and its relationship with diagnostic and prognostic parameters might help to improve the sensitivity of diagnosis as well as the efficacy of gastric cancer treatment. This review aims to highlight the advancements which might provide new methods for early clinical diagnosis and effective therapeutic options, along with predict response to treatment for gastric cancer.
微小 RNA（miRNAs）是由 18-23 个核苷酸组成的小单链 RNA 分子，作为癌基因或肿瘤抑制基因发挥作用，在肿瘤的发生、浸润和转移中发挥重要作用。随后，miRNAs 的表达有助于癌症的诊断和预后。胃癌目前在所有恶性肿瘤中发病率和死亡率都很高，但缺乏早期特异性诊断标志物和有效治疗方法。在胃癌中，许多研究已经检测到 miRNAs 的异常表达形式，并证实其参与了胃癌的发生、发展、浸润和转移。它们可能成为胃癌有价值的诊断标志物和治疗靶点。研究 miRNAs 在胃癌中的作用及其与诊断和预后参数的关系，可能有助于提高胃癌诊断的敏感性和治疗效果。本文综述旨在强调这些进展，为胃癌的早期临床诊断和有效治疗选择提供新方法，并预测其对治疗的反应。
