Khare Vaibhav, Alam Noor, Saneja Ankit, Dubey Ravindra Dhar, Gupta Prem N
J Biomed Nanotechnol. 2014 Dec;10(12):3462-82. doi: 10.1166/jbn.2014.2036.
Pancreatic cancer is usually diagnosed at the advanced stages, responds poorly to the available chemotherapeutics and constitutes the major factor for high mortality rate. Selective delivery of therapeutics to their cellular targets, without side effects is the foremost objective of the current investigations for effective treatment of pancreatic cancer. The development of the drugs which can selectively target pancreatic cancer along with carriers that can deliver drugs specifically to the rapidly dividing cells is considered as magic bullet for the efficient treatment of this fatal disease. This review describes various factors hampering the efficacy of drug targeting to pancreatic cancer including stromal fortress, hypocascularity, hyaluronan and interstitial fluid pressure, and exploration of various cellular targets for the site specific drug delivery. An account of burgeoning applications of novel drug delivery systems including nanoparticles, liposomes, quantum dots, micelles and drug conjugates in the management of pancreatic cancer is also provided. Additionally, potential of target based therapeutic agents and nanomedicines in clinical trials for the pancreatic cancer therapy are highlighted.
胰腺癌通常在晚期才被诊断出来，对现有的化疗药物反应不佳，是导致高死亡率的主要因素。在不产生副作用的情况下将治疗药物选择性地输送到其细胞靶点，是目前胰腺癌有效治疗研究的首要目标。开发能够选择性靶向胰腺癌的药物以及能够将药物特异性递送至快速分裂细胞的载体，被认为是有效治疗这种致命疾病的神奇子弹。本综述描述了阻碍药物靶向胰腺癌疗效的各种因素，包括基质屏障、血管减少、透明质酸和间质液压力，以及探索用于位点特异性药物递送的各种细胞靶点。还介绍了新型药物递送系统（包括纳米颗粒、脂质体、量子点、胶束和药物缀合物）在胰腺癌治疗中的新兴应用。此外，还强调了基于靶点的治疗药物和纳米药物在胰腺癌治疗临床试验中的潜力。
