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双侧症状性狭窄患者行外翻式颈动脉内膜切除术的围手术期结果

Perioperative results eversion carotid endarterectomy in bilateral symptomatic stenosis.

作者信息

Djedovic Muhamed, Djedovic Samed, Rustempasic Nedzad, Totic Dragan

机构信息

Clinic for vascular surgery, Clinical Center of University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

BH Heart Center Tuzla, Tuzla, Bosnia and Herzegovina.

出版信息

Med Arch. 2015 Apr;69(2):68-71. doi: 10.5455/medarh.2015.69.68-71. Epub 2015 Apr 6.

Abstract

INTRODUCTION

Carotid endarterectomy (CEA) is a standard treatment for the prevention of stroke and death in patients with significant stenosis of the internal carotid artery. Eversion endarterectomy is warranted in patients with symptoms of cerebral ischemia and the degree of stenosis of 70-99%. The same is suitable for treating a symptomatic carotid artery stenosis with contralateral stenosis (50-70%).

PURPOSE

The aim of this study was to evaluate perioperative complications (ICV, TIA, MI, mortality) in patients treated with carotid eversion endarterectomy with unilateral and bilateral symptomatic stenosis (with bilateral stenosis treated with ACI stenosis ≥70%).

PATIENTS AND METHODS

The study included 139 patients with symptomatic carotid artery stenosis at the Department of Vascular Surgery of the University Clinical Center of Sarajevo in the period from January 2012 to December 2014 year. Given the involvement of ACI stenosis patients were divided into two groups. Group A consisted of 74 patients with bilateral stenosis (surgically treated with ACI stenosis ≥70%, while the degree of stenosis opposite ACI was from 50-70%), and group B of 65 patients with unilateral stenosis ≥70%.

RESULTS

Of the 139 patients included in the study, in the group A was 74, of which 46 male (62.2%) and 28 female (37.8%), while in group B were 42 male (64.6%) and 23 female (35.4%) (p = 0.90). The subjects in group A were slightly older 65.9 (± 7.8) compared to group B 64.2 (± 7.7) (p = 0.17). Analysis of risk factors indicating a higher number in Group A compared to group B, but the difference was not statistically significant: 34 smokers (45.9%) versus 36 (55.4%); p = 0:34), patients with hypertension (63 (85.1%) against the 52 (80.0%); p = 0.56), with statin therapy (62 (83.8%) versus 52 (80.0%); p = 0.72), diabetes (18 (24.3%) versus 18 (27.7%); p = 0.79) and with a heart disease (18 (24.3%) versus 7 (10.8%); p = 0.06). Analysis of the frequency of perioperative complications between the groups was not statistically significant: ICV (2/74 versus 3/65; p = 1.00), TIA (2/74 versus 3/65; p = 0.88), one death was recorded in group A, while myocardial infarction (MI) we had in either group.

CONCLUSION

In this study, no statistically about significant differences in the number of perioperative complications (from 0 to 30 days) between the two groups. With this risk is acceptable to perform carotid endarterectomy in a patient in the opposite ACI stenosis of 50-70%.

摘要

引言

颈动脉内膜切除术(CEA)是预防颈内动脉严重狭窄患者中风和死亡的标准治疗方法。对于有脑缺血症状且狭窄程度为70 - 99%的患者,采用外翻式内膜切除术是必要的。这同样适用于治疗伴有对侧狭窄(50 - 70%)的有症状颈动脉狭窄。

目的

本研究的目的是评估接受单侧和双侧有症状狭窄(双侧狭窄采用≥70%的ACI狭窄治疗)的颈动脉外翻式内膜切除术患者的围手术期并发症(ICV、TIA、MI、死亡率)。

患者与方法

本研究纳入了2012年1月至2014年12月期间在萨拉热窝大学临床中心血管外科的139例有症状颈动脉狭窄患者。鉴于ACI狭窄的情况,患者被分为两组。A组由74例双侧狭窄患者组成(手术治疗ACI狭窄≥70%,而对侧ACI狭窄程度为50 - 70%),B组由65例单侧狭窄≥70%的患者组成。

结果

在纳入研究的139例患者中,A组74例,其中男性患者46例(62.2%),女性患者28例(37.8%);B组42例男性患者(64.6%),23例女性患者(35.4%)(p = 0.90)。A组患者年龄稍大,为65.9(±7.8)岁,而B组为64.2(±7.7)岁(p = 0.17)。危险因素分析表明A组的数量高于B组,但差异无统计学意义:吸烟者34例(45.9%)对36例(55.4%);p = 0.34),高血压患者(63例(85.1%)对52例(80.0%);p = 0.56),接受他汀类药物治疗(62例(83.8%)对52例(80.0%);p = 0.72),糖尿病患者(18例(24.3%)对18例(27.7%);p = 于0.79)和患有心脏病(18例(24.3%)对7例(10.8%);p = 0.06)。两组间围手术期并发症发生率的分析无统计学意义:ICV(2/74对3/65;p = 1.00),TIA(2/74对3/65;p = 0.88),A组记录到1例死亡,而两组均未发生心肌梗死(MI)。

结论

在本研究中,两组间围手术期并发症数量(0至)30天)无统计学显著差异。对于对侧ACI狭窄为50 - 70%的患者,进行颈动脉内膜切除术的这种风险是可接受的。

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