Barry Christopher T, Hazard Christopher, Hah Zaegyoo, Cheng Gang, Partin Alexander, Mooney Robert A, Chuang Kuang-Hsiang, Cao Wenqing, Rubens Deborah J, Parker Kevin J
Departments of Surgery (C.T.B., K.-H.C.), Pathology and Laboratory Medicine (R.A.M., W.C.), and Radiology (D.J.R.), University of Rochester Medical Center, Rochester, New York USA; GE Global Research, Niskayuna, New York USA (C.H.); Department of Electrical and Computer Engineering (Z.H., A.P., K.J.P.), University of Rochester, Rochester, New York USA; and GE Global Research, Shanghai, China (G.C.).
J Ultrasound Med. 2015 Jun;34(6):1123-9. doi: 10.7863/ultra.34.6.1123.
The precise measurement of fat accumulation in the liver, or steatosis, is an important clinical goal. Our previous studies in phantoms and mouse livers support the hypothesis that, starting with a normal liver, increasing accumulations of microsteatosis and macrosteatosis will increase the lossy viscoelastic properties of shear waves in a medium. This increase results in an increased dispersion (or slope) of the shear wave speed in the steatotic livers.
In this study, we moved to a larger animal model, lean versus obese rat livers ex vivo, and a higher-frequency imaging system to estimate the shear wave speed from crawling waves.
The results showed elevated dispersion in the obese rats and a separation of the lean versus obese liver parameters in a 2-dimensional parameter space of the dispersion (slope) and shear wave speed at a reference frequency of 150 Hz.
We have confirmed in 3 separate studies the validity of our dispersion hypothesis in animal models.
精确测量肝脏中的脂肪堆积，即脂肪变性，是一项重要的临床目标。我们之前在模型和小鼠肝脏中的研究支持这样一个假设：从正常肝脏开始，微脂肪变性和大脂肪变性的累积增加会使介质中剪切波的黏弹性损耗特性增加。这种增加导致脂肪变性肝脏中剪切波速度的频散（或斜率）增加。
在本研究中，我们转向更大的动物模型，即离体的瘦型与肥胖型大鼠肝脏，并采用更高频率的成像系统，通过蠕动波估计剪切波速度。
结果显示肥胖大鼠的频散升高，并且在150Hz参考频率下，在频散（斜率）和剪切波速度的二维参数空间中，瘦型与肥胖型肝脏参数出现分离。
我们在3项独立研究中证实了我们的频散假设在动物模型中的有效性。
