血清和佛波醇-12-肉豆蔻酸酯-13-乙酸酯在成纤维细胞中对小鼠c-rel基因的转录诱导
Transcriptional induction of the murine c-rel gene with serum and phorbol-12-myristate-13-acetate in fibroblasts.
作者信息
Bull P, Hunter T, Verma I M
机构信息
Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92138.
出版信息
Mol Cell Biol. 1989 Nov;9(11):5239-43. doi: 10.1128/mcb.9.11.5239-5243.1989.
Abstract
Transcription of the c-rel proto-oncogene was induced transiently when resting mouse NIH 3T3 fibroblasts were stimulated with serum or phorbol-12-myristate-13-acetate. Addition of cycloheximide increased the steady-state levels of c-rel mRNA. These results indicate that c-rel is another member of the early-response gene family.
摘要
当静止的小鼠NIH 3T3成纤维细胞用血清或佛波醇-12-肉豆蔻酸酯-13-乙酸酯刺激时，c-rel原癌基因的转录会被短暂诱导。添加放线菌酮可提高c-rel mRNA的稳态水平。这些结果表明c-rel是早期反应基因家族的另一个成员。
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