Caselli Anna, Cirri Paolo, Santi Alice, Paoli Paolo
Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Firenze, 50134 Firenze, Italy.
Curr Med Chem. 2016;23(8):774-91. doi: 10.2174/0929867323666160106150821.
Morin is a natural polyphenol, originally isolated from members of the Moraceae family that can be extracted from leaves, fruits, stems and branches of numerous plants. Several evidence have demonstrated that Morin could have a beneficial effect on several human diseases. In fact, Morin exerts antioxidant, antidiabetic, anti-inflammatory, antitumoral, antihypertensive, antibacterial, hypouricemic, and neuroprotective effects, by modulating the activity of many enzymes. In some cases, Morin shows a systemic protective action, reducing negative side effects of several drugs, without interfering with their functions. In addition, in vitro and in vivo studies demonstrated that Morin exhibits very low toxicity levels and its chronic administration is well tolerated. All these findings suggest that Morin could be used, either alone or in combination with other drugs, to prevent many human pathologies.
桑色素是一种天然多酚，最初从桑科植物中分离出来，可从多种植物的叶子、果实、茎和枝条中提取。多项证据表明，桑色素对多种人类疾病可能具有有益作用。事实上，桑色素通过调节多种酶的活性发挥抗氧化、抗糖尿病、抗炎、抗肿瘤、抗高血压、抗菌、降尿酸和神经保护作用。在某些情况下，桑色素显示出全身保护作用，可减少几种药物的负面副作用，而不干扰其功能。此外，体外和体内研究表明，桑色素的毒性水平非常低，其长期给药耐受性良好。所有这些发现表明，桑色素可单独使用或与其他药物联合使用，以预防许多人类疾病。
