无紫外线蓝光治疗寻常型轻度银屑病疗效及安全性的前瞻性随机长期研究
Prospective Randomized Long-Term Study on the Efficacy and Safety of UV-Free Blue Light for Treating Mild Psoriasis Vulgaris.
作者信息
Pfaff Stephanie, Liebmann Jörg, Born Matthias, Merk Hans F, von Felbert Verena
机构信息
Department of Dermatology and Allergology, University Hospital, RWTH Aachen University, Aachen, Germany.
出版信息
Dermatology. 2015;231(1):24-34. doi: 10.1159/000430495. Epub 2015 Jun 2.
BACKGROUND
Blue light irradiation reduces the proliferation of keratinocytes and modulates T-cell immune response in vitro and has been shown to reduce the severity of psoriasis vulgaris (Pv) in two clinical trials.
OBJECTIVE
Evaluation of safety and efficacy of long-term UV-free blue light treatment at home for mild Pv.
METHODS
Forty-seven patients with mild Pv were randomized for receiving high-intensity blue light treatment (HI: 453 nm LED, 200 mW/cm(2), n = 24) and low-intensity treatment (LI: 453 nm LED, 100 mW/cm(2), n = 23) of one Pv plaque for 12 weeks. A contralateral control plaque remained untreated.
RESULTS
Patient compliance and satisfaction were high. The primary endpoint, change from baseline (CfB) of the Local Psoriasis Severity Index, revealed a significant improvement of the target compared to the control plaques (ΔCfB for the HI group: -0.92 ± 1.10, p = 0.0005; for the LI group: -0.74 ± 1.18, p = 0.0064).
CONCLUSION
UV-free blue light home treatment is safe and improves Pv plaques.
背景
蓝光照射可在体外降低角质形成细胞的增殖并调节T细胞免疫反应，且在两项临床试验中已显示可减轻寻常型银屑病（Pv）的严重程度。
目的
评估在家中长期进行无紫外线蓝光治疗轻度Pv的安全性和有效性。
方法
47例轻度Pv患者被随机分为两组，分别接受高强度蓝光治疗（HI：453nm发光二极管，200mW/cm²，n = 24）和低强度治疗（LI：453nm发光二极管，100mW/cm²，n = 23），对一处Pv斑块进行为期12周的治疗。对侧对照斑块不进行治疗。
结果
患者的依从性和满意度较高。主要终点，即局部银屑病严重指数相对于基线的变化（CfB）显示，与对照斑块相比，目标有显著改善（HI组的ΔCfB：-0.92±1.10，p = 0.0005；LI组的ΔCfB：-0.74±1.18，p = 0.0064）。
结论
在家中进行无紫外线蓝光治疗是安全的，且可改善Pv斑块。
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