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使用蓝色有机发光二极管（OLED）的可穿戴光疗医学治疗新生儿黄疸：迈向基于纺织品的可穿戴光疗。

Wearable Photomedicine for Neonatal Jaundice Treatment Using Blue Organic Light-Emitting Diodes (OLEDs): Toward Textile-Based Wearable Phototherapeutics.

机构信息

School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.

Department of Biomedical Engineering, Gachon University, Seongnam, 13120, Republic of Korea.

出版信息

Adv Sci (Weinh). 2022 Dec;9(35):e2204622. doi: 10.1002/advs.202204622. Epub 2022 Oct 30.

DOI:10.1002/advs.202204622
PMID:36310107
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9762290/
Abstract

Neonatal jaundice is a very common disease in newborns and can lead to brain damage or death in severe cases. Phototherapy with light-emitting diode (LED) arrays is widely used as the easiest and fastest way to relieve jaundice in newborns, but it has distinct disadvantages such as loss of water in the patient, damage to the retina, and separation from parents. In this paper, a novel light source-based phototherapy for neonatal jaundice is proposed using a textile-based wearable organic light-emitting diode (OLED) platform that can move flexibly and conform to the curvature of the human body. The soft and flexible textile-based blue OLED platform is designed to have a peak wavelength of 470 nm, suitable for jaundice treatment, and shows performance (>20 µW cm nm ) suitable for intensive jaundice treatment even at low voltage (<4.0 V). The textile-based OLEDs fabricated in this study exhibit an operating reliability of over 100 h and low-temperature operation (<35 °C). The results of an in vitro jaundice treatment test using a large-area blue OLED confirm that the bilirubin level decreases to 12 mg dL with 3 h of OLED irradiation.

摘要

新生儿黄疸是新生儿中非常常见的疾病，在严重的情况下可能导致脑损伤或死亡。发光二极管 (LED) 阵列的光疗被广泛用作缓解新生儿黄疸的最简单、最快的方法，但它有明显的缺点，如患者失水、视网膜损伤和与父母分离。在本文中，提出了一种基于新型光源的新生儿黄疸光疗方法，使用基于纺织品的可穿戴有机发光二极管 (OLED) 平台，该平台可灵活移动并顺应人体的曲率。设计了一种软性和柔性的基于纺织品的蓝色 OLED 平台，其峰值波长为 470nm，适合黄疸治疗，并在低电压 (<4.0V) 下显示出适合高强度黄疸治疗的性能 (>20 µW cm nm)。本研究中制造的基于纺织品的 OLED 表现出超过 100 小时的运行可靠性和低温运行 (<35°C)。使用大面积蓝色 OLED 进行体外黄疸治疗测试的结果证实，经过 3 小时的 OLED 照射，胆红素水平降低到 12mg/dL。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1f/9762290/b4c12739626a/ADVS-9-2204622-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1f/9762290/93fdf1b2c0e3/ADVS-9-2204622-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1f/9762290/3fdad7165448/ADVS-9-2204622-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1f/9762290/88dcfd0b1ebe/ADVS-9-2204622-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1f/9762290/8eeb54e4adb4/ADVS-9-2204622-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1f/9762290/b4c12739626a/ADVS-9-2204622-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1f/9762290/93fdf1b2c0e3/ADVS-9-2204622-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1f/9762290/3fdad7165448/ADVS-9-2204622-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1f/9762290/88dcfd0b1ebe/ADVS-9-2204622-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1f/9762290/8eeb54e4adb4/ADVS-9-2204622-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1f/9762290/b4c12739626a/ADVS-9-2204622-g002.jpg

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