Finger Jacqueline H, Smith Constance M, Hayamizu Terry F, McCright Ingeborg J, Xu Jingxia, Eppig Janan T, Kadin James A, Richardson Joel E, Ringwald Martin
The Jackson Laboratory, Bar Harbor, Maine.
Genesis. 2015 Aug;53(8):510-22. doi: 10.1002/dvg.22864. Epub 2015 Jun 18.
The Gene Expression Database (GXD) is an extensive and freely available community resource of mouse developmental expression data. GXD curates and integrates expression data from the literature, via electronic data submissions, and by collaborations with large-scale projects. As an integral component of the Mouse Genome Informatics Resource, GXD combines expression data with genetic, functional, phenotypic, and disease-related data, and provides tools for the research community to search for and analyze expression data in this larger context. Recent enhancements include: an interactive browser to navigate the mouse developmental anatomy and find expression data for specific anatomical structures; the capability to search for expression data of genes located in specific genomic regions, supporting the identification of disease candidate genes; a summary displaying all the expression images that meet specified search criteria; interactive matrix views that provide overviews of spatio-temporal expression patterns (Tissue × Stage Matrix) and enable the comparison of expression patterns between genes (Tissue × Gene Matrix); data zoom and filter utilities to iteratively refine summary displays and data sets; and gene-based links to expression data from other model organisms, such as chicken, Xenopus, and zebrafish, fostering comparative expression analysis for species that are highly relevant for developmental research.
基因表达数据库（GXD）是一个广泛且免费的小鼠发育表达数据社区资源。GXD通过电子数据提交以及与大型项目的合作，整理并整合来自文献的表达数据。作为小鼠基因组信息资源的一个重要组成部分，GXD将表达数据与遗传、功能、表型及疾病相关数据相结合，并为研究社区提供工具，以便在更广泛的背景下搜索和分析表达数据。最近的改进包括：一个交互式浏览器，用于浏览小鼠发育解剖结构并查找特定解剖结构的表达数据；能够搜索位于特定基因组区域的基因的表达数据，支持疾病候选基因的识别；一个摘要，显示符合指定搜索标准的所有表达图像；交互式矩阵视图，提供时空表达模式的概述（组织×阶段矩阵），并能够比较基因之间的表达模式（组织×基因矩阵）；数据缩放和过滤实用程序，用于迭代优化摘要显示和数据集；以及基于基因的链接，指向来自其他模式生物（如鸡、非洲爪蟾和斑马鱼）的表达数据，促进对与发育研究高度相关的物种进行比较表达分析。
