Du Jin, Han Jichang, Li Xiandong, Zhang Yajun, Li Hongbing, Yang Shujuan
Department of Respiratory Medicine, Huaihe Hospital of Henan University Kaifeng, China.
Department of Health and Social Behavior, West China School of Public Health, Sichuan University Chengdu, China.
Int J Clin Exp Pathol. 2015 Mar 1;8(3):3225-9. eCollection 2015.
We conduct a case-control study to explore the possible association between IL-17 gene polymorphisms and development of TB.
The study population comprised 428 TB subjects and 428 control subjects between January 2013 and June 2014. Genotyping analyses of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 and rs9382084 were analyzed using polymerase chain reaction-restriction fragment length of polymorphism (PCR-RFLP).
The TB cases were more likely to have a habit of smoking when comparing with controls. By conditional logistic regression analysis, individuals carrying CC genotype of rs763780 were more likely to have a significantly increased risk of TB when compared with TT genotype. The OR (95% CI) for CC genotype of rs763780 was 2.98 (1.58-5.92).
In conclusion, we suggest that rs763780 play a critical role in the etiology of TB. These findings could be helpful in identifying individuals at increased risk for developing TB.
我们进行了一项病例对照研究，以探讨白细胞介素-17（IL-17）基因多态性与结核病发生之间的可能关联。
研究人群包括2013年1月至2014年6月期间的428例结核病患者和428例对照者。使用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析IL-17A的rs2275913和rs3748067以及IL-17F的rs763780和rs9382084的基因分型。
与对照组相比，结核病患者更有可能有吸烟习惯。通过条件逻辑回归分析，与TT基因型相比，携带rs763780的CC基因型个体患结核病的风险显著增加。rs763780的CC基因型的OR（95%CI）为2.98（1.58-5.92）。
总之，我们认为rs763780在结核病的病因学中起关键作用。这些发现可能有助于识别患结核病风险增加的个体。
