Oishi Mariko, Ohno Koichi, Sato Toru, Tamamoto Takashi, Kanemoto Hideyuki, Fukushima Kenjiro, Tsujimoto Hajime
Veterinary Medical Center and Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
J Vet Med Sci. 2015 Nov;77(11):1495-7. doi: 10.1292/jvms.15-0149. Epub 2015 Jun 5.
Pancreatic lipase immunoreactivity (Spec fPL) is currently considered to be the most accurate blood test for the diagnosis of feline pancreatitis. In this study, we measured lipase activity in cats using a newer catalytic lipase assay of dry-chemistry system (FDC-v-LIP) to determine the reference range and compared the results with those for Spec fPL. Based on the results of healthy cats, the reference range of FDC-v-LIP was determined to be less than 30 U/l. FDC-v-lip did not show a strong correlation with Spec fPL in cats with various diseases, which resulted in the low sensitivity and positive predictive value. However, the relatively high (>90%) specificity and negative predictive value indicated that FDC-v-LIP could be a useful patient-side screening test for the exclusion of feline pancreatitis.
胰腺脂肪酶免疫活性（特异性fPL）目前被认为是诊断猫胰腺炎最准确的血液检测方法。在本研究中，我们使用一种更新的干化学系统催化脂肪酶检测方法（FDC-v-LIP）测量猫的脂肪酶活性，以确定参考范围，并将结果与特异性fPL的结果进行比较。根据健康猫的检测结果，FDC-v-LIP的参考范围被确定为低于30 U/l。在患有各种疾病的猫中，FDC-v-LIP与特异性fPL没有显示出强相关性，这导致其敏感性和阳性预测值较低。然而，相对较高（>90%）的特异性和阴性预测值表明，FDC-v-LIP可能是一种有用的床边筛查检测方法，用于排除猫胰腺炎。
