Henley S Jane, Weir Hannah K, Jim Melissa A, Watson Meg, Richardson Lisa C
Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.
Cancer Epidemiol Biomarkers Prev. 2015 Sep;24(9):1319-26. doi: 10.1158/1055-9965.EPI-15-0199. Epub 2015 Jun 12.
Gallbladder cancer is a rare cancer with unusual distribution, and few population-based estimates for the United States have been published.
Using population-based cancer incidence and mortality data, we examined U.S. gallbladder cancer incidence and death rates for 2007-2011 and trends for 1999-2011.
During 2007 to 2011, approximately 3,700 persons were diagnosed with primary gallbladder cancer (rate = 1.13 cases per 100,000) and 2,000 died from the disease (rate = 0.62 deaths per 100,000) each year in the United States. Two thirds of gallbladder cancer cases and deaths occurred among women. Gallbladder cancer incidence and death rates were three times higher among American Indian and Alaska Native persons than non-Hispanic white persons. By state, gallbladder cancer incidence and death rates ranged by about 2-fold. During 1999 to 2011, gallbladder cancer incidence rates decreased among women but remained level among men; death rates declined among women but stabilized among men after declining from 1999 to 2006. Gallbladder cancer incidence rates increased in some subgroups, notably among black persons, those aged <45 years, and for endocrine tumors.
Data from U.S. population-based cancer registries confirm that gallbladder cancer incidence and death rates are higher among women than men, highest among American Indian and Alaska Native persons, and differ by region. While overall incidence and death rates decreased during 1999 to 2011, incidence rates increased among some small subgroups.
Surveillance of gallbladder cancer incidence and mortality, particularly to monitor increases in subgroups, may provide clues to etiology and stimulate further research.
胆囊癌是一种分布异常的罕见癌症，美国基于人群的相关估计数据鲜有发表。
利用基于人群的癌症发病率和死亡率数据，我们研究了2007 - 2011年美国胆囊癌的发病率和死亡率以及1999 - 2011年的趋势。
在2007年至2011年期间，美国每年约有3700人被诊断为原发性胆囊癌（发病率 = 每10万人中有1.13例），2000人死于该病（死亡率 = 每10万人中有0.62例死亡）。三分之二的胆囊癌病例和死亡发生在女性中。美国印第安人和阿拉斯加原住民的胆囊癌发病率和死亡率是非西班牙裔白人的三倍。按州划分，胆囊癌发病率和死亡率相差约两倍。在1999年至2011年期间，女性胆囊癌发病率下降，但男性保持稳定；女性死亡率下降，但在1999年至2006年下降后男性趋于稳定。一些亚组的胆囊癌发病率有所上升，尤其是黑人、45岁以下人群以及内分泌肿瘤患者。
美国基于人群的癌症登记数据证实，胆囊癌发病率和死亡率女性高于男性，在美国印第安人和阿拉斯加原住民中最高，且因地区而异。虽然1999年至2011年期间总体发病率和死亡率有所下降，但一些小亚组的发病率有所上升。
对胆囊癌发病率和死亡率的监测，特别是监测亚组中的增加情况，可能为病因提供线索并刺激进一步研究。
