Kobayashi J, Ishibashi M, Nakamura H, Ohizumi Y, Yamasu T, Hirata Y, Sasaki T, Ohta T, Nozoe S
Mitsubishi Kasei Institute of Life Sciences, Minamiooya, Machida, Tokyo, Japan.
J Nat Prod. 1989 Sep-Oct;52(5):1036-41. doi: 10.1021/np50065a021.
A fourth cytotoxic macrolide, amphidinolide D[1], together with known amphidinolide B[2], has been isolated from a different batch of the cultured dinoflagellate Amphidinium sp., which was symbiotically associated with an Okinawan flatworm Amphiscolops sp. Two-dimensional nmr experiments including 1H-detected heteronuclear multiple-bond correlation (HMBC) resulted in the structure assignment of 1 and structure revision of the diene moiety (C-13-C-15) of amphidinolide B.
