Liu Yingsong, Peng Hao, Meng Zhao, Wei Mingzhu
Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China (mainland).
Department of Orthopedics, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China (mainland).
Med Sci Monit. 2015 Jun 15;21:1732-6. doi: 10.12659/msm.893771.
The aim of this study was to evaluate the role of interleukin-17 (IL-17) level in synovia and its relationship with the severity of knee osteoarthritis (OA).
We enrolled 226 OA patients and 106 controls in this study. The symptomatic/radiation severity of OA was assessed by the Western Ontario McMaster University Osteoarthritis Index (WOMAC) pain score/Kellgren-Lawrence (KL) grading system. Serum IL-17 levels were measured by enzyme-linked immunosorbent assay (ELISA).
Synovia IL-17 levels were significantly higher in OA patients compared with controls (P<0.01), and were negatively correlated with OA severity. IL-17 level gradually decreased among different phases but lacked statistical significance.
IL-17 might play a crucial role in the pathogenesis of OA and is closely related to pain. Blocking the IL-17 signaling pathway may delay pain related to OA.
本研究旨在评估滑膜中白细胞介素-17（IL-17）水平的作用及其与膝关节骨关节炎（OA）严重程度的关系。
本研究纳入了226例OA患者和106例对照。通过西安大略和麦克马斯特大学骨关节炎指数（WOMAC）疼痛评分/凯尔格伦-劳伦斯（KL）分级系统评估OA的症状/放射学严重程度。采用酶联免疫吸附测定（ELISA）法检测血清IL-17水平。
与对照组相比，OA患者滑膜IL-17水平显著升高（P<0.01），且与OA严重程度呈负相关。IL-17水平在不同阶段逐渐降低，但缺乏统计学意义。
IL-17可能在OA发病机制中起关键作用，且与疼痛密切相关。阻断IL-17信号通路可能延缓与OA相关的疼痛。
