膝关节骨关节炎严重程度与血清及滑液白细胞介素17浓度之间的关联。
Association between severity of knee osteoarthritis and serum and synovial fluid interleukin 17 concentrations.
作者信息
Chen Biao, Deng Yu, Tan Yang, Qin Jun, Chen Liao-Bin
机构信息
Department of Orthopaedic Surgery, Zhongnan Hospital, Wuhan University, Wuhan, China.
出版信息
J Int Med Res. 2014 Feb;42(1):138-44. doi: 10.1177/0300060513501751. Epub 2013 Dec 6.
OBJECTIVE
To determine interleukin (IL)-17 concentrations in serum and synovial fluid from patients with knee osteoarthritis, and evaluate their correlation with disease severity.
METHODS
Serum and synovial fluid were collected from patients with primary knee osteoarthritis; age- and sex-matched healthy control subjects provided serum samples. This study was conducted retrospectively. IL-17 was quantified by enzyme-linked immunosorbent assay. Osteoarthritis severity and grade were assessed using the Lequesne index and Kellgren and Lawrence (KL) grading system, respectively.
RESULTS
Serum IL-17 concentrations were significantly higher in patients (n = 98) than in controls (n = 50). In the patient group, the synovial fluid IL-17 concentration increased significantly with KL grade and was significantly positively correlated with Lequesne index (r = 0.6232).
CONCLUSIONS
The synovial fluid IL-17 concentration could represent a useful biochemical marker to reflect knee osteoarthritis severity and progression.
目的
测定膝骨关节炎患者血清和滑液中白细胞介素（IL）-17的浓度，并评估其与疾病严重程度的相关性。
方法
收集原发性膝骨关节炎患者的血清和滑液；年龄和性别匹配的健康对照者提供血清样本。本研究为回顾性研究。采用酶联免疫吸附测定法对IL-17进行定量。分别使用Lequesne指数和Kellgren-Lawrence（KL）分级系统评估骨关节炎的严重程度和等级。
结果
患者（n = 98）血清IL-17浓度显著高于对照组（n = 50）。在患者组中，滑液IL-17浓度随KL分级显著升高，且与Lequesne指数显著正相关（r = 0.6232）。
结论
滑液IL-17浓度可能是反映膝骨关节炎严重程度和进展的有用生化标志物。
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