Hosseinpour-Niazi Somayeh, Mirmiran Parvin, Fallah-Ghohroudi Arefeh, Azizi Fereidoun
Nutrition and Endocrine Research Center, Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences,Tehran,Iran.
Department of Clinical Nutrition and Dietetics,Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences,Tehran,Iran.
Br J Nutr. 2015 Jul;114(2):213-9. doi: 10.1017/S0007114515001725. Epub 2015 Jun 16.
The present randomised cross-over clinical trial investigated the effects of two intervention diets (non-soya legume-based therapeutic lifestyle change (TLC) diet v. isoenergetic legume-free TLC diet) on inflammatory biomarkers among type 2 diabetic patients. A group of thirty-one participants (twenty-four women and seven men; weight 74.5 (SD 7.0) kg; age 58.1 (SD 6.0) years) were randomly assigned to one of the two following intervention diets for 8 weeks: legume-free TLC diet or non-soya legume-based TLC diet. The latter diet was the same as the legume-free TLC diet, except that two servings of red meat were replaced with different types of cooked non-soya legumes such as lentils, chickpeas, peas and beans over a period of 3 d per week. The intervention period was followed by a washout period of 4 weeks, after which the groups followed the alternate treatment for 8 weeks. Concentrations of inflammatory markers were measured at baseline and after the intervention periods. Compared with the legume-free TLC diet, the non-soya legume-based TLC diet significantly decreased high-sensitivity C-reactive protein, IL-6 and TNF-α in overweight diabetic patients. The replacement of two servings of red meat by non-soya legumes in the isoenergetic TLC diet for a period of 3 d per week reduced the plasma concentrations of inflammatory markers among overweight diabetic patients, independent of weight change.
本随机交叉临床试验研究了两种干预饮食（非大豆豆类治疗性生活方式改变（TLC）饮食与等能量无豆类TLC饮食）对2型糖尿病患者炎症生物标志物的影响。一组31名参与者（24名女性和7名男性；体重74.5（标准差7.0）kg；年龄58.1（标准差6.0）岁）被随机分配到以下两种干预饮食之一，为期8周：无豆类TLC饮食或非大豆豆类TLC饮食。后一种饮食与无豆类TLC饮食相同，只是在每周3天的时间里，用不同类型的煮熟非大豆豆类（如小扁豆、鹰嘴豆、豌豆和豆类）替代两份红肉。干预期之后是4周的洗脱期，之后各小组接受替代治疗8周。在基线和干预期结束后测量炎症标志物的浓度。与无豆类TLC饮食相比，非大豆豆类TLC饮食显著降低了超重糖尿病患者的高敏C反应蛋白、IL-6和TNF-α。在等能量TLC饮食中，每周3天用非大豆豆类替代两份红肉，可降低超重糖尿病患者血浆炎症标志物浓度，与体重变化无关。
